{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:42Z","timestamp":1790775462952,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS123080"],"award-info":[{"award-number":["R01NS123080"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS123165"],"award-info":[{"award-number":["R01NS123165"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS134887"],"award-info":[{"award-number":["R01NS134887"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS125464"],"award-info":[{"award-number":["R21NS125464"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","award":["85101\u2010NCA\u201022"],"award-info":[{"award-number":["85101\u2010NCA\u201022"]}],"id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","award":["85113\u2010NCA\u201023"],"award-info":[{"award-number":["85113\u2010NCA\u201023"]}],"id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Serine protease inhibitor clade A member 3n (Serpina3n) or its human orthologue SERPINA3 is a secretory immune\u2010related molecule produced primarily in the liver and brain under homeostatic conditions and up\u2010regulated in response to system inflammation. Yet, it remains elusive regarding its cellular identity and physiological significance in the development of the postnatal brain. Here, we reported that oligodendroglial lineage cells are the major cell population expressing Serpina3n protein in the postnatal murine CNS. Using loss\u2010of\u2010function genetic tools, we found that Serpina3n conditional knockout (cKO) from Olig2\u2010expressing cells does not significantly affect cognitive and motor functions in mice. Serpina3n depletion does not appear to interfere with oligodendrocyte differentiation and developmental myelination nor affects the population of other glial cells and neurons in\u00a0vivo. Interestingly, Serpina3n is significantly up\u2010regulated in response to oxidative stress and its deficiency alleviates oxidative injury and diminishes cell senescence of oligodendrocytes in\u00a0vitro. Together, our data suggest that the immune\u2010related molecule Serpina3n plays a minor role in neural cell development under homeostasis, yet it primes oligodendrocytes for CNS insults and regulates oligodendrocyte health under injured conditions. Our findings raise the interest in pursuing its functional significance in the CNS under disease\/injury conditions.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16250-fig-0011-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16250","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T05:57:07Z","timestamp":1729835827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dispensable regulation of brain development and myelination by the immune\u2010related protein Serpina3n"],"prefix":"10.1111","volume":"169","author":[{"given":"Meina","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine, UC Davis Institute for Pediatric Regenerative Medicine (IPRM), Shriners Hospitals for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, UC Davis Institute for Pediatric Regenerative Medicine (IPRM), Shriners Hospitals for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, UC Davis Institute for Pediatric Regenerative Medicine (IPRM), Shriners Hospitals for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annlin","family":"Titus","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, UC Davis Institute for Pediatric Regenerative Medicine (IPRM), Shriners Hospitals for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-8389","authenticated-orcid":false,"given":"Fuzheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, UC Davis Institute for Pediatric Regenerative Medicine (IPRM), Shriners Hospitals for Children  Sacramento California 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