{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:55:11Z","timestamp":1787774111421,"version":"build-2784847793"},"reference-count":88,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vascular dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). While sodium is essential for maintaining vascular function, its role in AD pathology remains unclear. We included 353 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI), assessing serum sodium levels, cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers, magnetic resonance imaging (MRI), and cognitive function. An independent sample (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009471) with available CSF sodium\u2010related proteins and AD biomarkers was also included. Associations between serum sodium levels and AD pathology, neurodegeneration, and cognition were evaluated using linear regression models. Spearman's correlation analyses assessed the relationships between CSF sodium\u2010related proteins and AD biomarkers. Higher serum sodium levels were associated with increased AD pathology, reduced hippocampal volume, and greater cognitive decline (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The relationship between serum sodium and amyloid PET was evident in several AD\u2010susceptible brain regions, including the neocortex and limbic system. Individuals with high serum sodium exhibited higher tau pathology, lower hippocampal volume, and more severe cognitive decline per unit increase in amyloid PET compared to those with low serum sodium (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Among the 14 CSF sodium\u2010related proteins, which were inter\u2010correlated, six were significantly correlated with CSF AD pathology and amyloid PET, while two were correlated with hippocampal volume and cognitive function, with sodium channel subunit beta\u20102 (SCN2B) and sodium channel subunit beta\u20103 (SCN3B) showing the strongest correlations. These findings underscore the crucial role of serum sodium in AD progression, highlighting a potential network of sodium dysregulation involved in AD pathology. Targeting sodium may offer a novel therapeutic approach to slowing AD progression, particularly by impeding the progression of amyloid\u2010related downstream events.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16257-fig-0006-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16257","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T10:00:28Z","timestamp":1730887228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated serum sodium is linked to increased amyloid\u2010dependent tau pathology, neurodegeneration, and cognitive impairment in Alzheimer's disease"],"prefix":"10.1111","volume":"169","author":[{"given":"Yu\u2010Han","family":"Chen","sequence":"first","affiliation":[{"name":"The First Clinical Medical School Hebei North University  Zhangjiakou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Hebei North University  Zhangjiakou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-4531","authenticated-orcid":false,"given":"Zhi\u2010Qi","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging 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