{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:32:11Z","timestamp":1772839931027,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271475\/32300824"],"award-info":[{"award-number":["82271475\/32300824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein found in microglia within the brain, and its soluble form (sTREM2) has been shown to reduce amyloid deposition. Whether elevated TREM2\u2010mediated microglial activity decreases the risk of Alzheimer's disease (AD) is unclear. The aim of this study was to assess whether high cerebrospinal fluid (CSF) levels of sTREM2 attenuate the risk of\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    \u2010associated amyloid pathology. We included 877 cognitively intact subjects from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study, including\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    carriers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009136) and non\u2010carriers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009741). The linear regression was used to examine the interaction effect between CSF sTREM2 levels and APOE \u03b54 status on CSF A\u03b242 levels. Additionally, subgroup analyses stratified by sex and age were conducted. Our main finding was that higher concentrations of CSF sTREM2 attenuated the effect of\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    carriage (i.e., the sTREM2\u2009\u00d7\u2009\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    interaction) on amyloid deposition (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22122.701e\u201005,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Subgroup analyses showed that the effect of interaction was still significant only in male (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041) and mid\u2010life (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013) subgroups. Our study suggested that in cognitively intact individuals, changes in sTREM2 levels are associated with biomarkers of AD, and higher concentrations of CSF sTREM2 attenuated the risk of\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    \u2010related amyloid pathology. The identified role of the sTREM2\u2009\u00d7\u2009\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    interaction in amyloid pathology offers new insights into potential strategies for AD prevention in\n                    <jats:italic>APOE \u03b54<\/jats:italic>\n                    carriers.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16273-fig-0006-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16273","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T23:14:27Z","timestamp":1735254867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Higher\n                    <scp>CSF sTREM2<\/scp>\n                    attenuates\n                    <i>APOE \u03b54<\/i>\n                    \u2010related risk for amyloid pathology in cognitively intact adults: The\n                    <scp>CABLE<\/scp>\n                    study"],"prefix":"10.1111","volume":"169","author":[{"given":"Yong\u2010Chang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Hua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Shandong Second Medical University  Weifang Shandong 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