{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:12:07Z","timestamp":1793365927927,"version":"4.5.0"},"reference-count":158,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic neuropathic pain is a debilitating condition that presents a significant therapeutic challenge. Unlike nociceptive pain, neuropathic pain is predominantly driven by glutamate NMDA receptors (NMDARs) and\/or Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010permeable AMPA receptors (CP\u2010AMPARs) at synapses between primary afferent nerves and excitatory neurons in the spinal dorsal horn. The \u03b12\u03b4\u20101 protein, encoded by\n                    <jats:italic>Cacna2d1<\/jats:italic>\n                    and historically recognized as a subunit of voltage\u2010activated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels, is the primary target of gabapentinoids, such as gabapentin and pregabalin, which are widely prescribed for neuropathic pain and epilepsy. However, gabapentinoids have minimal effects on Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel activity. Recent studies reveal that \u03b12\u03b4\u20101 plays a pivotal role in amplifying nociceptive input to the spinal cord in neuropathic pain. This action is mediated through its dynamic physical interactions with phosphorylated NMDARs and GluA1\/GluA2 subunits via its intrinsically disordered C\u2010terminal region. \u03b12\u03b4\u20101 not only promotes synaptic trafficking of NMDARs but also disrupts heteromeric assembly of GluA1\/GluA2 subunits in the spinal dorsal horn. The central function of \u03b12\u03b4\u20101 is to elevate intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentrations at both presynaptic and postsynaptic sites, augmenting nociceptive transmission. Consequently, \u03b12\u03b4\u20101 serves as a dual regulator coordinating synaptic expression of NMDARs and GluA1 homomeric CP\u2010AMPARs, a function that underlies the therapeutic actions of gabapentinoids. By inhibiting \u03b12\u03b4\u20101, gabapentinoids reduce the hyperactivity of synaptic \u03b12\u03b4\u20101\u2010bound NMDARs and CP\u2010AMPARs, thereby dampening the excessive excitatory synaptic transmission characteristic of neuropathic pain. These newly identified roles of \u03b12\u03b4\u20101 in orchestrating glutamatergic synaptic plasticity suggest that gabapentinoids could be repurposed for treating other neurological disorders involving dysregulated synaptic NMDARs and CP\u2010AMPARs.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70064-fig-0006-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70064","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:25:19Z","timestamp":1744007119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["\u03b12\u03b4\u20101\u2010Linked\n                    <scp>NMDA<\/scp>\n                    and\n                    <scp>AMPA<\/scp>\n                    Receptors in Neuropathic Pain and Gabapentinoid Action"],"prefix":"10.1111","volume":"169","author":[{"given":"Yuying","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-3770","authenticated-orcid":false,"given":"Hui\u2010Lin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.12.039"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0356-09.2009"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.05.007"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.07.013"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.12.014"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38711-2"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90049-7"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108667"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.39.25458"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20115"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2019.1579098"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.021"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90193-2"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504183102"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.306"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1282"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)36427-4"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.021"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050030"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1704-22.2022"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.263814"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200112000-00029"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.261339"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.215855"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.208363"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14627"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-00951-7"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.024"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20693"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908735107"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012076"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002648"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03047-y"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2055"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-43"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-5172.2004.0329.x"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200209000-00007"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000055433.55136.55"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200007000-00035"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52655-y"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.025"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00173-8"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/wmts.93"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.048"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409066103"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.02.032"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00122.2009"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2616\u201017.2018"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5768"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107848"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.06.011"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-001-0072-7"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.03.005"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00693-1"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524358113"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.05.032"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0172-7"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11033"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222010958"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0183-23.2023"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1943\u201023.2023"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0282-20.2020"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14677"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1968-21.2021"},{"key":"e_1_2_15_66_1","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0392-24.2024","article-title":"Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via \u03b12\u03b4\u20101 in Spinal Excitatory Neurons","volume":"44","author":"Huang Y.","year":"2024","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)49986-3"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15706"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21143"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43802"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S107350"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5561-06.2007"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12123FP"},{"key":"e_1_2_15_74_1","first-page":"147","article-title":"Effects of Mirogabalin, a Novel Ligand for the Alpha(2)delta Subunit of Voltage\u2010Gated Calcium Channels, on N\u2010Type Calcium Channel Currents of Rat Dorsal Root Ganglion Culture Neurons","volume":"74","author":"Kitano Y.","year":"2019","journal-title":"Pharmazie"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1099925"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0803p.x"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00347"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24531"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4165"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47507-2"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2982-04.2004"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.04.022"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.039"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109396"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.054"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.18.8383"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022330"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.041574"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-06-01868.2001"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0447-18.2018"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP276394"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704227"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00520-7"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(24)12585-0"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1194-8"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.045"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000323"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.019"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.7.843"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005940107"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00188-7"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25437"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38054-1"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.723478"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1026-13.2013"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01268.x"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14408"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_57_19"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(93)90023-Z"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1551"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1837"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08390.x"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201611586"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01387.x"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244422.45278.ff"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.211"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01198.x"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277428"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130391"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2002.11753609"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.05.053"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.266056"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.026"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01472\u20106"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.002451"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003428"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3420313"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3602"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19321"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1148697"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.073429"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.075523"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.06.027"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.732347"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.818476"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28429-y"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(89)90160-7"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2016.01.006"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(92)90198\u2010K"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0499-20.2021"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2011.06.004"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12679"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(98)80060-3"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0303-21.2021"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0735-22.2022"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.073"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.378737"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.395830"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5857-09.2010"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.11.17"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003977"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15573"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP286081"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0346-21.2021"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320976"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322562"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0757-21.2021"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae1333"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:53:03Z","timestamp":1748231583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":158,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jnc.70064"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70064","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.70064\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70064\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70064\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70064\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70064\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70064"}}