{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:25:05Z","timestamp":1788193505952,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Calcium is essential for the growth of neurons during infancy as well as transmission of signals between neurons; thus, the related signaling pathways might contribute to the pathogenesis of brain disorders. Voltage\u2010gated calcium channels are widely expressed in the trigeminovascular system and are regarded as important contributors to some forms of familial migraines. In fact, these channels participate in the migraine initiation events. We compared the expression of genes coding for ion channels, including\n                    <jats:italic>SLC1A1<\/jats:italic>\n                    ,\n                    <jats:italic>SLC25A12<\/jats:italic>\n                    ,\n                    <jats:italic>ATP2B2<\/jats:italic>\n                    , and their associated lncRNAs, namely\n                    <jats:italic>LINC01231<\/jats:italic>\n                    ,\n                    <jats:italic>lnc\u2010SLC25A12<\/jats:italic>\n                    , and\n                    <jats:italic>lnc\u2010MTR\u20101<\/jats:italic>\n                    , between migraineurs and healthy controls. All mentioned genes and lncRNAs, except for\n                    <jats:italic>ATP2B2<\/jats:italic>\n                    and\n                    <jats:italic>LINC01231<\/jats:italic>\n                    , were shown to be up\u2010regulated in total migraineurs compared with controls. Moreover, the expression levels of ATP2B2 were higher in patients with aura compared with those without aura (Expression ratio (95% CI)\u2009=\u20095.83 (2.93\u201311.59),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Yet, SLC25A12 was down\u2010regulated in patients with aura as compared with those without aura (Expression ratio (95% CI)\u2009=\u20090.21 (0.11\u20130.42),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Notably, we demonstrated high specificity and sensitivity values for some genes in the differentiation of migraineurs from healthy controls. Taken together, we demonstrated significant over\u2010expression of a number of ion channel and transporter genes and their related lncRNAs in migraineurs and suggested these genes as potential markers for this neurological condition.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70112-fig-0004-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70112","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:50:24Z","timestamp":1749693024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Calcium Signaling Related Genes in Migraine"],"prefix":"10.1111","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-0591","authenticated-orcid":false,"given":"Mohammad","family":"Taheri","sequence":"first","affiliation":[{"name":"Institute of Human Genetics Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Pourtavakoli","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solat","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Medicine Alborz University of Medical Sciences  Karaj Iran"},{"name":"Non\u2010Communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezou","family":"Sayad","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudeh","family":"Ghafouri\u2010Fard","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010021\u201001285\u20109"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2023.2176984"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/pri.21767"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10933"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.05.062"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(17)30435\u20100"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2024.03.010"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-14-05366.1997"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/8.2.108"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010020\u201001788\u20101"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0069\u201007.2007"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2012.07.001"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(97)11370\u20108"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116151"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2013.9001"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(16)31678\u20106"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416628463"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416686769"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.44.27715"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5347-11.2012"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2023.05.067"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237539.09942.06"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2023.100971"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010023\u201009182\u2010x"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa921"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.042"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8070406"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010024\u201002513\u20100"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201045341\u20107"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10090615"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks915"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(12)61729\u20102"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061021"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T15:22:35Z","timestamp":1752938555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jnc.70112"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70112","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.70112\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70112\/v4\/decision1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70112"}}