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The biochemical and molecular pathways associated with AD are complex, making it difficult to study and simulate in patients or through in\u00a0vitro research. Thus, animal models play a crucial role in investigating the development and progression of AD. One widely used model in neuroscience studies is the free\u2010living nematode\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    ). The development of transgenic animals has allowed for the construction of the\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006)\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain, which constitutively expresses the amyloid beta (A\u03b2) peptide. This study conducted a proteomic analysis on the\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006) strain. Also, a cross\u2010species comparative analysis was performed using microarray data from AD patients to identify genes with ontology in the\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006). A total of 543 proteins were found to be differentially regulated in the\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006) strain. Furthermore, in the analysis of the human datasets, 397 upregulated and 767 downregulated genes were identified. The differentially expressed genes (DEGs) were analyzed in Ortholist to identify their orthologs in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Then, the orthologous genes in the\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006) model were compared to the proteomic data, resulting in the identification of 29 upregulated and 24 downregulated proteins (DEPs). Functional enrichment analysis of DEPs revealed terms related to pyruvate, glucose, and glutamate metabolism, in addition to binding activities to unfolded proteins and ligases, highlighting the upregulation of chaperone and ubiquitination\u2010associated proteins. Protein\u2013protein network (PPI) was performed for the human DEGs and DEPs of\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006). Topological analyses of the networks were performed, revealing the following\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C. elegans<\/jats:styled-content>\n                      hub\n                    <\/jats:italic>\n                    proteins: EEF\u20102, ALH\u201013, ENOL\u20101, RPL\u20102, TPI\u20101, CTS\u20101, RPL\u20109, RPL\u201023, CCT\u20101, and RPS\u20108. eEF\u20102 was identified as a key regulator of the human AD PPI and\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006). Modules were analyzed in the networks, and the presence of key regulators was identified. This study provides the first proteomic characterization of the AD model\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006) and a cross\u2010species comparative analysis with data from AD individuals, supporting the use of\n                    <jats:italic>dvls2<\/jats:italic>\n                    (CL2006) in AD studies.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70152-fig-0009-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70152","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T06:35:31Z","timestamp":1752474931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Label\u2010Free Proteomic Profiling of the\n                    <i>dvls2<\/i>\n                    (\n                    <scp>CL2006<\/scp>\n                    )\n                    <i>Caenorhabditis elegans<\/i>\n                    Alzheimer's Disease (\n                    <scp>AD<\/scp>\n                    ) Model Reveals Conserved Molecular Signatures Shared With the Human\n                    <scp>AD<\/scp>\n                    Brain"],"prefix":"10.1111","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-8913","authenticated-orcid":false,"given":"Iverson Conrado","family":"Bezerra","sequence":"first","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"},{"name":"Graduate Program in Biology Applied to Health, PPGBAS Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Raphaely Souza","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarine G. Aurista","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"},{"name":"Graduate Program in Biology Applied to Health, PPGBAS Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Jos\u00e9","family":"da Silva","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"},{"name":"Graduate Program in Biology Applied to Health, PPGBAS Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josivan Barbosa","family":"de Farias","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"},{"name":"Graduate Program in Biology Applied to Health, PPGBAS Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza de Lima","family":"Vitorino","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"},{"name":"Graduate Program in Biology Applied to Health, PPGBAS Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Afonso","family":"da Silva","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luiz de Lima","family":"Filho","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-8050","authenticated-orcid":false,"given":"Priscila","family":"Gubert","sequence":"additional","affiliation":[{"name":"Keizo Asami Institute, iLIKA Federal University of Pernambuco  Recife Brazil"},{"name":"Graduate Program in Biology Applied to Health, PPGBAS Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101796"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00279"},{"key":"e_1_2_10_4_1","article-title":"Modeling Alzheimer's Disease in Caenorhabditis elegans","volume":"10","author":"Alvarez J.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.04.033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1052"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.113.150847"},{"key":"e_1_2_10_10_1","volume-title":"A Blueprint for Dementia Research","author":"Brain Health (BRH) Mental Health, Brain Health and Substance Use (MSD)","year":"2022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00461"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-019-02063-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"Brostrom C. 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