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This clinical study, conducted at the tertiary memory clinic of Karolinska University Hospital in Stockholm, evaluates plasma pTau217 (in comparison to other plasma biomarkers) as a non\u2010invasive marker for predicting brain amyloid load and cognitive impairment. Uniquely, it integrates plasma biomarkers with cognitive profiling and amyloid PET to assess diagnostic utility across disease stages in a real\u2010world memory clinic setting. A total of 122 patients underwent extensive clinical examinations, including CSF analysis (used here for clinical diagnosis only), CT\/MRI, neuropsychological (NP) testing (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200980) and blood biomarker measurements. Prior to PET imaging, 74 patients were diagnosed with MCI among other diagnoses (AD, other dementia, no dementia). Following PET, patients were reclassified into diagnostic groups: MCI A\u03b2\u2212 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929), MCI A\u03b2+ (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919), AD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951), other dementias (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911). ROC analysis evaluated the ability of plasma biomarkers to predict A\u03b2\u2010PET positivity. NP test\n                    <jats:italic>z<\/jats:italic>\n                    \u2010scores were reduced into principal components (PCs) using PCA. Plasma pTau217 and pTau217\/A\u03b242 ratio were elevated in A\u03b2+ patients compared to MCI A\u03b2\u2010patients. The ratio distinguished MCI A\u03b2+ from AD and, together with pTau217, showed the highest predictive value for A\u03b2 positivity in the MCI group among the biomarkers analyzed (AUC 92.8% and 91.4%). Plasma pTau217\/A\u03b242 ratio was associated with principal component PC2 (\u201cmemory encoding and recall\u201d) in MCI A\u03b2+ (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=0.64, p=0.01) and negatively correlated with RAVL retrieval (PC2) in the same group (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u22120.57 and \u22120.6, p=0.028 and 0.017, respectively). Additionally, pTau217 correlated with the \u201cInformation\u201d\n                    <jats:italic>z<\/jats:italic>\n                    \u2010score (PC4) in both AD (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u2009\u22120.50,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and MCI A\u03b2+ (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.53,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042). Plasma pTau217\/A\u03b242 might be a valuable predictor of brain amyloid pathology and a potential marker of domain\u2010specific cognitive impairment in AD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70182-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70182","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:53:33Z","timestamp":1754898813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Profiling Plasma Biomarkers, Particularly pTau217 and pTau217\/A\u03b242, and Their Relation to Cognition in Memory Clinic Patients"],"prefix":"10.1111","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-8651","authenticated-orcid":false,"given":"Marco","family":"Bucci","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics Karolinska Institutet  Stockholm Sweden"},{"name":"Turku PET Centre Turku University Central Hospital and University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Almkvist","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bluma","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Savitcheva","sequence":"additional","affiliation":[{"name":"Medical Radiation Physics and Nuclear Medicine Karolinska University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Chiotis","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Neurology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Di Molfetta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal 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