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In addition to attractive and miracle\u2010looking possibilities, the major obstacle for the industry is complicated, unpredictable, and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain\u2013implant interface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells\u2014the glial scar\u2014has been studied previously for its role in brain trauma. This review highlights pharmacological and tissue engineering avenues that could be readily transferred from the brain trauma area to fast\u2010growing neuroimplant engineering. The opportunities for chondroitinase ABC treatment, stem cells, and hydrogels for the prevention of glial scarring are emphasized. Alternatively, the glial scar may also be viewed not as an obstacle but as a possible regeneration\u2010permissive component of the optimally working brain\u2013neuroimplant interface. Feasible steps in that direction are discussed, including applications for chondroitin sulfate\u2010binding peptides. Finally, the crucial role of new microscopy and data processing techniques for peri\u2010implant glial scar monitoring is highlighted. To that end, we stress the importance of artificial intelligence, including artificial neuronal networks, for the analysis of cell morphology at the brain\u2013neuroimplant interface.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70203-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70203","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T05:00:12Z","timestamp":1756875612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroimplants and the Glial Scar: What Makes the Brain\u2013Computer Link Work?"],"prefix":"10.1111","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2905-2272","authenticated-orcid":false,"given":"Mikhail","family":"Paveliev","sequence":"first","affiliation":[{"name":"Institute of Physics Kazan Federal University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-1075","authenticated-orcid":false,"given":"Anastasiia","family":"Melnikova","sequence":"additional","affiliation":[{"name":"Institute of Physics Kazan Federal University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-8616","authenticated-orcid":false,"given":"Anton A.","family":"Egorchev","sequence":"additional","affiliation":[{"name":"Institute of Computational Mathematics and Information Technologies Kazan Federal University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-2197","authenticated-orcid":false,"given":"Vladimir","family":"Parpura","sequence":"additional","affiliation":[{"name":"International Translational Neuroscience Research Institute Zhejiang Chinese Medical University  Hangzhou P.R. 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