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Ube3a maternal deficient mice replicate many key behavioral deficits associated with AS; however, the underlying molecular mechanisms remain poorly understood. Using an RT\n                    <jats:sup>2<\/jats:sup>\n                    Profiler PCR array that summarizes the expression of 84 genes regulating synaptic plasticity, we identified a number of dysregulated genes in the visual cortex of AS mice brains at postnatal day 25 (P25) compared to wild\u2010type animals. In\u2010depth analysis revealed that various immediate early genes (IEGs), like Arc, Egr1\u20104, and Homer, are dramatically downregulated in the visual cortex of AS mice with regard to wild\u2010type controls at P25. Moreover, the dark rearing of wild\u2010type mice considerably decreased the levels of these IEGs to nearly the same level as those found in AS mice, along with the downregulation of Ube3a. Furthermore, a significant reduction in the expression of these IEGs can also be observed in the hippocampus of AS mice. Finally, we demonstrate that the augmented activity of Hdac2 in the AS mice brain might be connected with the downregulation of various IEGs and other synaptic plasticity\u2010regulating genes. These findings indicate that the deregulated expression of neural activity\u2010dependent IEGs could be linked with abnormal synaptic plasticity and associated behavioral deficits observed in AS mice.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70238-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  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