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However, as evidence progressively challenged this concept by unveiling phenotypes that are regulated according to a pattern of sexual dimorphism, many studies were undertaken to identify the mechanisms driving sex\u2010specific characteristics. In this context, hypothalamic brain\u2010derived neurotrophic factor emerged as an important player regulating metabolism according to a sexual dimorphic pattern. Here, we performed a narrative review that puts together the main pieces of evidence showing how brain\u2010derived neurotrophic factor is involved in metabolic sexual dimorphism. The accumulated data in this field has uncovered important aspects of the physiological and pathological control of metabolic sex\u2010specific functions and has placed hypothalamic brain\u2010derived neurotrophic factor as a potential target for interventions aimed at mitigating metabolic abnormalities that affect differently females and males.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70245-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  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