{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:21:45Z","timestamp":1773876105746,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patients with chronic pain often present with depression, and the specific neuronal populations and circuits underlying this phenomenon are yet to be fully characterized. Here, using a neuropathic pain model, we found that the development of chronic pain is accompanied by anxiety\u2010 and depressive\u2010like behavior. Concurrently, we observed increased activity of Pro\u2010opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), and acute inhibition of this elevated ARC\n                    <jats:sup>POMC<\/jats:sup>\n                    neuron activity could reverse the behavioral manifestations of depression. While activating POMC neurons in na\u00efve mice did not induce significant behavioral changes, stimulating these neurons during the early phase of peripheral nerve injury promoted susceptibility to depression, thereby inducing depressive phenotypes. Further studies established a projection pathway from the ARC to the central amygdala (CeA), which controls the development of depressive\u2010like behaviors in states of chronic neuropathic pain, rather than those due to chronic stress. These findings collectively indicate that chronic pain leads to persistent hyperactivity of POMC neurons. Our discoveries suggest that POMC neuronal dysfunction contributes to behavioral deficits associated with chronic pain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70249-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70249","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:52:11Z","timestamp":1762505531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role and Mechanism of Arcuate Nucleus\n                    <scp>POMC<\/scp>\n                    Neurons in Depression\u2010Like Behavior of Chronic Pain"],"prefix":"10.1111","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0361-8457","authenticated-orcid":false,"given":"Tianbao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University  Yiwu China"},{"name":"School of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kairan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanbing","family":"Diao","sequence":"additional","affiliation":[{"name":"School of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingzhong","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Gao","sequence":"additional","affiliation":[{"name":"The Yangzhou Clinical Medical College of Xuzhou Medical University  Yangzhou Jiangsu China"},{"name":"Department of Anesthesiology Northern Jiangsu People's Hospital  Yangzhou Jiangsu China"},{"name":"Yangzhou Key Laboratory of Anesthesiology Northern Jiangsu People's Hospital  Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3153"},{"issue":"1","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pain.2005.10.036","article-title":"Assessment and Analysis of Mechanical Allodynia\u2010Like Behavior Induced by Spared Nerve Injury (SNI) in the Mouse","volume":"122","author":"Bourquin A. 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