{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:21:51Z","timestamp":1773876111344,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIBAA MARCORA 0499 R73060"],"award-info":[{"award-number":["PIBAA MARCORA 0499 R73060"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PICT\u20102019\u201001457 Marcora M silvina"],"award-info":[{"award-number":["PICT\u20102019\u201001457 Marcora M silvina"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PICT\u20102019\u20100621KatzMaximiliano"],"award-info":[{"award-number":["PICT\u20102019\u20100621KatzMaximiliano"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PICT\u20102021\u2010GRF\u2010TI\u201000036 Marcora M Silvina"],"award-info":[{"award-number":["PICT\u20102021\u2010GRF\u2010TI\u201000036 Marcora M Silvina"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Iron deficiency (ID) is the most common micronutrient deficiency globally. ID in pre\u2010 and post\u2010natal periods has been associated with impaired neurological development and altered behavior, which may persist despite iron supplementation. However, the neurobiological changes responsible for these findings have not been fully identified yet. Here, we develop an invertebrate experimental model using\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    <\/jats:styled-content>\n                    to study the impact of ID on glial cells. ID induced by dietary deferoxamine altered locomotor activity in adult flies. Glial\u2010specific downregulation of the iron transporter\n                    <jats:italic>Malvolio<\/jats:italic>\n                    (\n                    <jats:italic>Mvl<\/jats:italic>\n                    ) resulted in reduced locomotion, an effect prevented by iron supplementation in the fly medium. We confirmed that\n                    <jats:italic>Mvl<\/jats:italic>\n                    downregulation led to ID in the brain, where Mvl is partially expressed. Interestingly,\n                    <jats:italic>Mvl<\/jats:italic>\n                    reduction in ensheathing glia replicated locomotor activity deficits, which suggests that this glial subpopulation is particularly sensitive to iron levels.\n                    <jats:italic>Mvl<\/jats:italic>\n                    downregulation also altered mitochondrial morphology and size, in correlation with altered expression of mitochondrial fission and fusion genes, and mitochondrial electron transport chain complex genes. These results suggest that glial ID impairs normal mitochondrial dynamics and impacts energy production. Additionally, glial overexpression of mitochondrial ferritin,\n                    <jats:italic>Fer3HCH<\/jats:italic>\n                    , known to induce ID in the cytosol and mitochondria, also impaired locomotor activity, which highlights the importance of iron availability in both compartments. These findings demonstrate, for the first time, the importance of iron availability in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    glial cells and its impact on behavior and mitochondrial dynamics. Most importantly, the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    model proves useful in unveiling previously unknown cellular and molecular mechanisms associated with ID in glial cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70272-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70272","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:34:30Z","timestamp":1762767270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron Deficiency in\n                    <i>Drosophila melanogaster<\/i>\n                    Glial Cells Impacts Behavior Through Altered Mitochondrial Dynamics"],"prefix":"10.1111","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-7965","authenticated-orcid":false,"given":"Mar\u00eda S.","family":"Marcora","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica and Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gica (IQUIFIB), Facultad de Farmacia y Bioqu\u00edmica UBA\u2010CONICET  Buenos, Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-1833","authenticated-orcid":false,"given":"Maximiliano J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Bernardo Houssay (IFIBIO Houssay\u2010CONICET)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azul","family":"Galo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Bernardo Houssay (IFIBIO Houssay\u2010CONICET)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Bochicchio","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biolog\u00eda Experimental, Laboratorio de Neuroetolog\u00eda de Insectos Universidad de Buenos Aires (UBA)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Bernardo Houssay (IFIBIO Houssay\u2010CONICET)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego H.","family":"Bod\u00edn","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biolog\u00eda Experimental, Laboratorio de Neuroetolog\u00eda de Insectos Universidad de Buenos Aires (UBA)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario R.","family":"Pagani","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Bernardo Houssay (IFIBIO Houssay\u2010CONICET)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4854-4763","authenticated-orcid":false,"given":"Jorge D.","family":"Correale","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica and Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gica (IQUIFIB), Facultad de Farmacia y Bioqu\u00edmica UBA\u2010CONICET  Buenos, Aires Argentina"},{"name":"Instituto de Investigaciones Neurol\u00f3gicas Dr. Ra\u00fal Carrea, FLENI  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-0228","authenticated-orcid":false,"given":"Juana M.","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica and Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gica (IQUIFIB), Facultad de Farmacia y Bioqu\u00edmica UBA\u2010CONICET  Buenos, Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21133"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1468S"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.23.020102.075739"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.051664"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cris.2021.100017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.5.931"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091420962681"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20101136(199606)17:2<83::AID\u2010GLIA1>3.0.CO;2\u20107"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/363941"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105372200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5951\u201008.2009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020552"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02179499"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05603\u201011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201000663\u20102"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.02.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.530527"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.09.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abk2432"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0098\u20102997(00)00006\u20106"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111212"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.131169"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.08.004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.160.11.1108"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109053251004"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.93604"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25334"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601471103"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.02.031"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005645\u2010z"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(95)90178\u20107"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026462\u2010x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi227"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868\u2010019\u20100507\u20107"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460\u20102075.1995.tb07303.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010016\u20100369\u20102"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010015\u20101344\u20105"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.118"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1211"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14107"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20784"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.08.002"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70117\u20106"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.8.981"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104934"}],"updated-by":[{"DOI":"10.1111\/jnc.70411","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000}}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70272","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:44:38Z","timestamp":1773848678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jnc.70272"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70272","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.70272\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70272\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70272\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70272\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70272\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70272\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70272\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70272"}}