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This control incorporates both homeostatic and hedonic systems, contingent upon whether it is responding to nutritional status or to the reward mechanisms associated with food consumption. The lateral septum (LS) functions as a pivotal neural relay center, exerting an effect on alimentary intake upon activation. Due to its extensive neural connections with other cerebral nuclei, the LS is integrated with circuits governing both homeostatic and hedonic feeding controls. Recent investigations have elucidated a connection between the glucagon\u2010like peptide 1 (GLP\u20101) system and the LS, revealing that the activation of the GLP\u20101 receptor (GLP\u20101R) within this region modulates food intake. We present several recent findings highlighting the critical role of the LS in food intake control, alongside the importance of the GLP\u20101 system within this neural context. Additionally, we advocate for further research on the GLP\u20101\/GLP\u20101R system in the LS as a therapeutic target for obesity.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70301-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70301","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:35:07Z","timestamp":1763987707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lateral Septum as a Key Integrative Regulator of Feeding: Role of the\n             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