{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:22:22Z","timestamp":1789438942773,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1A6A3A01086738"],"award-info":[{"award-number":["NRF\u20102021R1A6A3A01086738"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1F1A1049744"],"award-info":[{"award-number":["NRF\u20102021R1F1A1049744"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parkinson's disease (PD) is driven by mitochondrial impairment and oxidative stress\u2013induced dopaminergic cell death. Phosphoglycerate mutase 5 (PGAM5) augmented accelerating mitophagy and attenuating neuronal apoptosis. Here, we present a novel cell\u2010penetrating PEP\u20101\u2010PGAM5 fusion protein designed to suppress oxidative damage and apoptosis. We assessed its transduction efficiency and neuroprotective efficacy in\u00a0vitro and in\u00a0vivo. PEP\u20101\u2010PGAM5 was efficiently transduced into SH\u2010SY5Y cells without cytotoxicity. In MPP\n                    <jats:sup>+<\/jats:sup>\n                    \u2010exposed cells, PEP\u20101\u2010PGAM5 attenuated ROS generation, prevented DNA fragmentation, and restored apoptotic signaling. In PD animal model, PEP\u20101\u2010PGAM5 crossed the blood\u2013brain barrier, preserved tyrosine hydroxylase\u2013positive neurons, and modulated apoptosis markers. These findings demonstrate that delivery of mitochondrial phosphatase PGAM5 via PEP\u20101 not only mitigates key PD pathologies but also establishes a versatile platform for delivering therapeutic proteins to the brain. PEP\u20101\u2010PGAM5 thus represents a promising candidate for PD and other neurodegenerative disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70324-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70324","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T15:02:33Z","timestamp":1766761353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuroprotective Effects of\n                    <scp>PEP<\/scp>\n                    \u20101\u2010\n                    <scp>PGAM5<\/scp>\n                    via the Attenuation of Oxidative Stress and Apoptosis in Parkinson's Disease"],"prefix":"10.1111","volume":"169","author":[{"given":"Hyun Jung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences, College of Dentistry, Gangneung\u2010Wonju National University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Institute of Veterinary Science, Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Veterinary Medicine Research Institute for Veterinary Science, Seoul National University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Myung","family":"Moon","sequence":"additional","affiliation":[{"name":"Research Institute for Complementary &amp; Alternative Medicine Hallym University  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8785-4508","authenticated-orcid":false,"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences, College of Dentistry, Gangneung\u2010Wonju National University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1997.69031196.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.031"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13731"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2022.10.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010130230"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.7.197"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.170"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.01.003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3406"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105346"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61393\u20103"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","unstructured":"Kyu Ri Hahn H. 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