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The ChP, an epithelial tissue located in each brain ventricle, experiences a decline in key functions, including protein secretion and CSF production. A critical gap in our understanding of the ChP lies in its lipid composition and the potential impact of age\u2010related changes on its physiology. This study hypothesized that the lipidome of the lateral ventricle choroid plexus (LVCP) is modulated during aging, potentially generating pro\u2010inflammatory mediators. To address this, we performed quantitative lipidomics on LVCP from male and female mice across aging and investigated whether pro\u2010inflammatory lipid mediators increase with age. LVCP and cortex tissues from C57BL\/6 mice aged 6, 12, 18, and 24\u2009months (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095\/age\/sex) were analyzed using liquid chromatography\u2013tandem mass spectrometry, and data were processed using Lipidr and univariate statistical methods. Given the pronounced sex differences, analyses were stratified by sex. During aging, 9 lipids in males and 19 in females were significantly modulated. In males, most changes occurred at 24\u2009months and involved higher levels of arachidonic acid (ARA) in alkyl ether and plasmalogen phosphatidylcholine species. In females, most changes occurred at 18\u2009months and were characterized by lower levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), whereas at 24\u2009months, females exhibited higher levels of EPA, DHA, and ARA in alkyl ether and plasmalogens compared to other ages. Additionally, younger females showed higher levels of oxygenated derivatives of linoleic acid compared to older females. These findings reveal dynamic, sex\u2010specific remodeling of the LVCP lipidome during aging, suggesting that lipid homeostasis in this structure is tightly regulated and may influence inflammatory signaling and barrier function in an age\u2010dependent manner.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70329-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70329","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T13:51:30Z","timestamp":1766497890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Lipidome of the Lateral Ventricle Choroid Plexus Exhibits Sex\u2010Specific Changes Across Aging"],"prefix":"10.1111","volume":"169","author":[{"given":"Gaby","family":"Loupiac","sequence":"first","affiliation":[{"name":"Research Center on Aging, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et Services Sociaux de l'Estrie\u2010Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9 Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Institute of Nutrition and Functional Foods  Qu\u00e9bec Qu\u00e9bec 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