{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:51:39Z","timestamp":1791726699295,"version":"4.3.4"},"reference-count":166,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Familial cerebral cavernous malformations (FCCM) are a heritable neurovascular disorder defined by clusters of dilated, thin\u2010walled capillaries in the brain and spinal cord. Although rare, FCCM offers a tractable model for understanding how genetic disruptions in endothelial junction biology, mechanotransduction, and kinase signaling drive vascular instability in the central nervous system. Pathogenic loss\u2010of\u2010function variants converge on signaling abnormalities that promote barrier dysfunction, iron deposition, inflammation, and progressive lesional growth. Clinically, FCCM may manifest with seizures, headaches, focal deficits, or intracerebral hemorrhage, yet many carriers remain asymptomatic owing to incomplete and age\u2010dependent penetrance. Advances in neuroimaging have enhanced the detection of micro\u2010lesions and iron accumulation, establishing these modalities as central biomarkers of disease expression. Complementing imaging, emerging circulating biomarkers, including inflammatory cytokines and plasma microRNAs associated with mutation status, may improve individualized risk stratification. This primer synthesizes current knowledge on FCCM pathophysiology, genetics, diagnostic strategies, and therapeutic perspectives. By integrating molecular mechanisms with clinical relevance, it outlines a framework for understanding FCCM as a disorder of perturbed endothelial signaling and neurovascular homeostasis, and highlights opportunities to advance precision medicine for this challenging condition.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70342-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70342","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:52:33Z","timestamp":1767595953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-0927","authenticated-orcid":false,"given":"Fabr\u00edcia Lima","family":"Fontes\u2010Dantas","sequence":"first","affiliation":[{"name":"Neuropharmacogenetics Laboratory, Department of Pharmacology and Psychobiology, Roberto Alcantara Gomes Institute Biology (IBRAG) Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"da Fontoura Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Martins","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"},{"name":"Department of Surgical Specialties, Neurosurgery Division Pedro Ernesto University Hospital, Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"de Sena Murteira Pinheiro","sequence":"additional","affiliation":[{"name":"Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica","family":"Morandi","sequence":"additional","affiliation":[{"name":"Laboratory of Endothelial Cell Biology and Angiogenesis (LabAngio), Department of Cell Biology, Roberto Alcantara Gomes Institute Biology (IBRAG) Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-8239","authenticated-orcid":false,"given":"Jorge Marcondes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000003459"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn430"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083794"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975024012709"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.1200"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115576"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arrct.2022.100191"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S14744422(25)000365"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.3.JNS181724"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000121"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.13990004.2012.01892.x"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.177"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.843"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102421"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/426952"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480125"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027207"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974022023852"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2009.05.002"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/14710528.17046"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200870"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44393"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s4159801948448y"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356839"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s1089701700720"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110438"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.2.188"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2025.124023"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.1.JNS141452"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505433"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101430130456z"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.04.019"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31820773cf"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0748"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38028"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20947"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456020097368"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313970"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14773"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.13652249.2005.02961.x"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201303044"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8937"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507789"},{"key":"e_1_2_16_45_1","volume-title":"GeneReviews","author":"Flemming K. D.","year":"2023"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c04340"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s0070100609298"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439022024585"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e318211ff8b"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107947"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010023\u201001131\u2010x"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814544364"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000249188.38409.03"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000157586.20479.fd"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s0023402203056y"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010403"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.5.JNS16687"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.15.118"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010017\u20100561\u20103"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312680"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000347009.32480.D8"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.3.FOCUS1165"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000183616.99139.d3"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604113341503"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.155"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251314366"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471237751"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000722"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14546"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab117"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167139"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010141294y"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031761"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00051"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033487"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701019040750"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0022093022030139"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(07)70053\u20104"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000338"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1090"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S14744422(22)004094"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.004753"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.1.0038"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.971164"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104914"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598025911416"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154909"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62155"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1086\/510439"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.216093"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood201806856062"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171178"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122577"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975019007374"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12207"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263025011980"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s4146701910707x"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61519"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1227\/0000612319951000000001"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq433"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu153"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.625467"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975019007258"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1338941"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s1203101608068"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086286"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/kinasesphosphatases1010006"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000684"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s0041500603599"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn420"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.07.003"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2018"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043993"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.03.101"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2023.119488"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet\u20102019\u2010106182"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010022\u201004355\u20106"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.12.016"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s1004801303620"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975022010503"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12402"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003810173434x"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.12.2325"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s1304501602830"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415024128053"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15253"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8120624"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.032"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802750RR"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s1014301304786"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902888R"},{"key":"e_1_2_16_132_1","first-page":"169","volume-title":"Methods in Molecular Biology","author":"Schwefel K.","year":"2020"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s120310160863z"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00953"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S14744422(22)004409"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967022033604"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.024058"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.97"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.538769"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaf077"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456025099855"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020335"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.755"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486292"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx450"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091258"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200263"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.2.0342"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000043"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4724"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22075"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw3521"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2025.123581"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.5.0903"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.97"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000210"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048\u2010007\u20100098\u20109"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.04.005"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1911"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.049935"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7429"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022314"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s413740180030y"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102469"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17178"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S14744422(19)302315"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000206888"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:17:22Z","timestamp":1773029842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":166,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jnc.70342"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70342","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.70342\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70342\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70342\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70342\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70342\/v1\/review1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70342"}}