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To unravel the neuroprotective roles and underlying mechanisms of SA\n                    <jats:bold>1\u20134<\/jats:bold>\n                    against oxidative injury and healthy longevity crosstalk, a combination of in\u00a0vitro experiments, in silico modeling, and network pharmacology was employed. Pretreatment with SA\n                    <jats:bold>1\u20134<\/jats:bold>\n                    in human neuronal SH\u2010SY5Y cells significantly regulated sirtuins (SIRTs)\/forkhead box class O 3a (FOXO3a)\u2010mediated longevity signaling pathway via targeting endogenous antioxidant enzymes (i.e., superoxide dismutase 2 [SOD2] and catalase [CAT]), apoptotic cascades (i.e., Bcl\u20102\u2010associated X\u2010protein [BAX] and B\u2010cell lymphoma\u20102 [BCL\u20102]), mitochondrial balance, and ultimately led to the neuronal rescue. Molecular docking simulations support the possibility of the SA\n                    <jats:bold>1\u20134<\/jats:bold>\n                    modulatory effect within the active binding site of SIRT1. Importantly, in silico predictions of pharmacokinetic profiles suggested that the synthetic compounds possessed preferable drug\u2010like properties, good oral bioavailability, and safety profiles. Network pharmacology also revealed the involvement of SA\n                    <jats:bold>1\u20134<\/jats:bold>\n                    and key targets\u2010regulated SIRTs in neurodegeneration, including non\u2010amyloidogenic cascade, tau phosphorylation, calcium homeostasis, insulin\u2010mediated glucose uptake, and neuroinflammation. Therefore, SA\n                    <jats:bold>1\u20134<\/jats:bold>\n                    exert promising multi\u2010target therapeutic strategies against oxidative damage, potentially offering alternative anti\u2010Alzheimer candidates for further clinical neurodegenerative and anti\u2010aging therapeutics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70377-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70377","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:01:02Z","timestamp":1771560062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unraveling Network Pharmacology\u2010Based Therapeutics of Anthranilate Sulfonamides via Sirtuins\/\n                    <scp>FOXO3a<\/scp>\n                    Cascade in Alzheimer's Disease"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-3780","authenticated-orcid":false,"given":"Waralee","family":"Ruankham","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, Faculty of Medical Technology Mahidol University  Bangkok 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