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While multiple cell death pathways have been implicated, ferroptosis has recently emerged as a critical mechanism. This iron\u2010dependent form of regulated cell death is driven by the accumulation of phospholipid hydroperoxides, leading to oxidative membrane damage. Dopaminergic neurons are intrinsically vulnerable to ferroptosis due to their high iron content, active dopamine metabolism (a source of reactive oxygen species), and relatively low antioxidant defenses. Here we synthesize evidence linking ferroptosis to dopaminergic neurodegeneration in Parkinson's disease and related conditions, detailing the molecular mechanisms involving iron dyshomeostasis, lipid peroxidation, and \u03b1\u2010synuclein pathology. We further evaluate growing preclinical data demonstrating that pharmacological inhibition of ferroptosis is neuroprotective and discuss the clinical implications, therapeutic potential, and ongoing challenges of translating these findings into effective treatments for patients.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70438-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70438","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:04:36Z","timestamp":1776067476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["When Pathways Converge: Iron, Lipid Peroxidation, and \u03b1\u2010Synuclein in Ferroptosis\u2010Driven Dopaminergic Neurodegeneration"],"prefix":"10.1111","volume":"170","author":[{"given":"Carmem L.","family":"Sperlich","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"},{"name":"Graduate Program on Neurosciences, Center of Biological Sciences Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent R.","family":"Stockwell","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Columbia University  New York New York USA"},{"name":"Department of Chemistry Irving Institute for Cancer Dynamics, and Data Science Institute  New York New York USA"},{"name":"Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center Columbia University Digestive and Liver Disease Research Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-8515","authenticated-orcid":false,"given":"Marcelo","family":"Farina","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"},{"name":"Graduate Program on Neurosciences, Center of Biological Sciences Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"},{"name":"Graduate Program on Biochemistry, Center of Biological Sciences Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina 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