{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:49:32Z","timestamp":1789775372716,"version":"4.0.1"},"reference-count":141,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydroxytyrosol (HTyr), a phenolic compound present in olive oil, exhibits antioxidant, anti\u2010inflammatory, and neuroprotective properties, benefiting several age\u2010related diseases. Our previous research demonstrated that oral HTyr administration counteracts age\u2010associated neurogenesis decline in the dentate gyrus of the hippocampus by promoting the production of stem\/progenitor cells and new neurons. Since new neurons generated in the dorsal dentate gyrus support contextual memory discrimination, while those generated in the ventral region modulate anxiety, we investigated whether pure HTyr, synthesized in our laboratories, selectively stimulates neurogenesis in these regions in aging mice and evaluated its effects on contextual memory and stress response. Furthermore, we examined its influence on gut microbiota composition, given the well\u2010established role of the microbiota\u2010gut\u2010brain axis in memory and stress regulation. We found that HTyr induced the production of new neurons and neuroblasts in both dentate gyrus regions, with a prevalent effect in the ventral region. Consistently, we observed that HTyr treatment did not improve the contextual memory discrimination but reduced fear sensitization and anxiety\u2010like behavior after a traumatic experience. Furthermore, we observed a reduction of neuroinflammation in HTyr\u2010treated dentate gyri. In parallel, treatment with HTyr preserved the stability of key microbial families linked to intestinal well\u2010being, counteracting the unhealthy effects of stress on gut microbial structure. Our results suggest that HTyr treatment in aging mice enhances resilience to posttraumatic stress by increasing neurogenesis and modulating the microbiota\u2010gut\u2010brain axis. Future studies should explore its potential as a therapeutic intervention for individuals experiencing posttraumatic stress disorder symptoms.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70448-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70448","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:59:31Z","timestamp":1777553971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hydroxytyrosol Mitigates Anxiety\u2010Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition"],"prefix":"10.1111","volume":"170","author":[{"given":"Giorgio","family":"D'Andrea","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bertini","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences University of Tuscia  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Costanzi","sequence":"additional","affiliation":[{"name":"Department of Human Sciences LUMSA University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-6318","authenticated-orcid":false,"given":"Fabiana","family":"Canini","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences University of Tuscia  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bernini","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Forest Sciences (DAFNE) University of Tuscia  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fochetti","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Forest Sciences (DAFNE) University of Tuscia  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Clemente","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Forest Sciences (DAFNE) University of Tuscia  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences University of Tuscia  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-1600","authenticated-orcid":false,"given":"Manuela","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR)  Rome Italy"},{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences University of Tuscia  Viterbo Italy"},{"name":"Institute for Sustainable Plant Protection National Research Council of Italy  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizia","family":"Caruso","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-6753","authenticated-orcid":false,"given":"Ferdinando","family":"Scavizzi","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology National Research Council of Italy (IBBC\u2010CNR\/EMMA\/INFRAFRONTIER\/IMPC)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-2430","authenticated-orcid":false,"given":"Marcello","family":"Raspa","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology National Research Council of Italy (IBBC\u2010CNR\/EMMA\/INFRAFRONTIER\/IMPC)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-4377","authenticated-orcid":false,"given":"Felice","family":"Tirone","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-7261","authenticated-orcid":false,"given":"Laura","family":"Micheli","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180794"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.10.019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.010"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020378"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.45"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0262-4"},{"issue":"1","key":"e_1_2_13_8_1","first-page":"1","article-title":"Chemistry of Hydrogen Sulfide\u2014Pathological and Physiological Functions in Mammalian Cells","volume":"12","author":"Andr\u00e9s C. M. C.","year":"2023","journal-title":"Cells"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01105-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.01.019"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"issue":"2150","key":"e_1_2_13_12_1","first-page":"1","article-title":"The Effects of the Mediterranean Diet on Health and Gut Microbiota","volume":"15","author":"Barber T. M.","year":"2023","journal-title":"Nutrients"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00669"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986713804999367"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf801558z"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.030"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/d5030627"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02733.x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.03.015"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213665"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00207-0"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.647259"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b00408"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90335-D"},{"key":"e_1_2_13_26_1","article-title":"Interaction Between Neurogenic Stimuli and the Gene Network Controlling the Activation of Stem Cells of the Adult Neurogenic Niches, in Physiological and Pathological Conditions","volume":"8","author":"Ceccarelli M.","year":"2020","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.08.014"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283654258"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2021"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1244"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1469281"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40764-7_10"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2175811"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00279"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.147"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3346"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-007-0728-0"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902643R"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b00627"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.03.005"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12305"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.01.059"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adu9575"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.03.009"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq461"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1835-6"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104921"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1679"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00124"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060246"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3125"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00060-5"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.241429"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1128623"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22746"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09357.2003"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.07.043"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23982"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.594448"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/6365"},{"issue":"4","key":"e_1_2_13_61_1","first-page":"006","article-title":"The Role of BDNF\u2010TrkB Signaling in the Pathogenesis of PTSD","volume":"2013","author":"Green C. R.","year":"2013","journal-title":"Journal of Depression and Anxiety"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01443-2"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109256"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053126"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.10.031"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.41"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12826"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12820"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21082"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.08.010"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5236"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.86104"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1847"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-09-03206.1998"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.038"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2919"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152112399"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010037"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.07.035"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-148452"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10945"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau4760"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012348"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-05824-x"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.315227"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac312"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.03.026"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1875796"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112488"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/2470547017713297"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-013-0027-6"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0539-6"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0936-17.2017"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140263"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111579"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071767"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.08.023"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01986"},{"key":"e_1_2_13_100_1","first-page":"193","volume-title":"Handbook of Experimental Pharmacology","author":"Nagpure B. V.","year":"2015"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-171124"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01306.x"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.09.011"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2018.05.011"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4925"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00097A"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56408-9"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.009"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v12.i1.77"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.30"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34502-3"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.79.3.152"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.04.005"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081776"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.08.007"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0483-15.2015"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-18-07153.2001"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.02.024"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0109-9"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10091869"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1364.025"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.08.032"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.07.017"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00025"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0134-5"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20407"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.015"},{"issue":"5","key":"e_1_2_13_131_1","first-page":"1531","article-title":"Hydroxytyrosol Promotes Autophagy by Regulating SIRT1 Against Advanced Oxidation Protein Product\u2010Induced NADPH Oxidase and Inflammatory Response","volume":"44","author":"Sun T.","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00059"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13427"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071774"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150610141524"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.301026"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22265"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00114"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.149286"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1283769"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001318"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902862"}],"updated-by":[{"DOI":"10.1111\/jnc.70471","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000}}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70448","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T06:31:30Z","timestamp":1779863490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":141,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jnc.70448"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70448","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"2025-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70448"}}