{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:04:38Z","timestamp":1779865478539,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 11220200102807CO01"],"award-info":[{"award-number":["PIP 11220200102807CO01"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Understanding the mechanisms that underlie neuronal dynamics is crucial to promoting brain health. The chromatin\u2010modifying protein RCOR2 (also named CoREST2) has recently gained attention for its neuroprotective roles. Although previous work has firmly established RCOR2's importance in neurogenesis and aging, its contributions to post\u2010mitotic neurons remain understudied. This gap limits our ability to unveil its broader significance for brain health. In this study, we used the rat primary culture of embryonic hippocampal neurons, highly enriched in pyramidal glutamatergic neurons, to show that RCOR2 preserves the structural integrity of axons and dendrites. By combining state\u2010of\u2010the\u2010art imaging techniques, including confocal, AiryScan2, and STED microscopy, we unveiled that RCOR2 is highly packed within neuronal nuclei, where it maintains the spatial organization of heterochromatin. The delivery of shRNA sequences targeting RCOR2, either by transient transfection or lentiviral infection, led to its partial knockdown and a pronounced shortening of axons and dendrites. This phenotype was paralleled by an abnormal accumulation of microtubule\u2010associated proteins (MAPs), including MAP2 and Tau, revealed by qRT\u2010PCR, immunoblotting, and confocal imaging. Strikingly, RCOR2 knockdown neurons show increased axonal MAP2, suggesting the loss of axonal identity. Moreover, z\u2010stack imaging revealed an abnormal increase in the tyrosinated\u2010tubulin\/acetylated\u2010tubulin ratio\u2014a molecular marker of microtubule (MT) stability\u2014indicating reduced MT stability. In this regard, the treatment with a nanomolar and MT\u2010stabilizing dose of taxol (3\u2009nM) partially rescued the neuritic growth of RCOR2 knock\u2010down neurons, suggesting a MT\u2010dependent mechanism. These findings unveil neuron\u2010specific functions of RCOR2, highlighting its protective role in sustaining neuronal architecture during early development.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70465-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70465","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:26:14Z","timestamp":1779168374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Chromatin\u2010Modifying Protein\n                    <scp>RCOR2<\/scp>\n                    \/\n                    <scp>CoREST2<\/scp>\n                    Safeguards Axon\u2010Dendrite Growth and Microtubule Stability in Brain Neurons"],"prefix":"10.1111","volume":"170","author":[{"given":"Carlos","family":"Wilson","sequence":"first","affiliation":[{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC) I Centro de Investigaci\u00f3n en Medicina Traslacional \u201cSevero R. Amuch\u00e1stegui\u201d (CIMETSA) U.A. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET); Av. Naciones Unidas 420, Barrio Parque V\u00e9lez Sarsfield, X5016KEJ \u2013  C\u00f3rdoba Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Cordoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-107X","authenticated-orcid":false,"given":"Victoria","family":"Roz\u00e9s\u2010Salvador","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Cordoba Argentina"},{"name":"Facultad de Ciencias Qu\u00edmicas, Centro de Investigaci\u00f3n en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI) Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 F.","family":"Drube","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC) I Centro de Investigaci\u00f3n en Medicina Traslacional \u201cSevero R. Amuch\u00e1stegui\u201d (CIMETSA) U.A. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET); Av. Naciones Unidas 420, Barrio Parque V\u00e9lez Sarsfield, X5016KEJ \u2013  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s M.","family":"Cardozo Gizzi","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC) I Centro de Investigaci\u00f3n en Medicina Traslacional \u201cSevero R. Amuch\u00e1stegui\u201d (CIMETSA) U.A. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET); Av. Naciones Unidas 420, Barrio Parque V\u00e9lez Sarsfield, X5016KEJ \u2013  C\u00f3rdoba Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Cordoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f3nimo","family":"Salguero","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC) I Centro de Investigaci\u00f3n en Medicina Traslacional \u201cSevero R. Amuch\u00e1stegui\u201d (CIMETSA) U.A. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET); Av. Naciones Unidas 420, Barrio Parque V\u00e9lez Sarsfield, X5016KEJ \u2013  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lis","family":"Moyano","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC) I Centro de Investigaci\u00f3n en Medicina Traslacional \u201cSevero R. Amuch\u00e1stegui\u201d (CIMETSA) U.A. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET); Av. 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