{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:41:57Z","timestamp":1790854917343,"version":"4.1.0"},"reference-count":209,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Elevated levels of the inflammatory cytokine IL\u20106 and decreased levels of cholesterol in blood and brain tissue have been reported in studies of individuals who attempted or completed suicide. The mechanisms underlying these effects remain unclear. In this review, we discuss a potential mechanistic link between these observations involving lipid raft function and serotonergic signaling. Reduced cholesterol availability may affect lipid raft function and could, potentially through reduced levels of the lipid raft protein S100A10 (p11), result in diminished cell\u2010surface expression of the serotonin receptors 5\u2010HT\n                    <jats:sub>1B<\/jats:sub>\n                    and 5\u2010HT\n                    <jats:sub>4<\/jats:sub>\n                    . Both receptors have been implicated in the suppression of impulsive and aggressive behavior. Lipid rafts are also organizing platforms for GABA, glutamate, and serotonin transporters. Reduced serotonin reuptake could contribute to the often\u2010reported decrease in the serotonin metabolite 5\u2010hydroxyindoleacetic acid (5\u2010HIAA) in suicidal individuals. Inflammatory cytokines, including IL\u20106, may further influence serotonergic signaling by increasing expression of the enzyme indoleamine\u20102,3\u2010dioxygenase (IDO), which enhances tryptophan degradation through the kynurenine pathway. Reduced tryptophan availability may limit serotonin synthesis and thereby decrease activation of the 5\u2010HT\n                    <jats:sub>1B<\/jats:sub>\n                    and 5\u2010HT\n                    <jats:sub>4<\/jats:sub>\n                    receptors. These observations suggest that the combined effects of low cholesterol, elevated IL\u20106 signaling, and reduced tryptophan availability may increase impulsivity and thereby heighten vulnerability to suicidal behavior. This framework accommodates findings from genetic and biomarker studies in suicidal patients. Owing to its effect on lipid raft organization, the fish\u2010oil component docosahexaenoic acid (DHA) might modulate these processes and potentially reduce suicide risk in individuals with low cholesterol levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70466-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70466","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:48:18Z","timestamp":1778741298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low\n                    <scp>\n                      5HT\n                      <sub>1B<\/sub>\n                    <\/scp>\n                    and\n                    <scp>\n                      5HT\n                      <sub>4<\/sub>\n                    <\/scp>\n                    Receptor Neurotransmission as a Potential Link Between Cholesterol Metabolism and Suicide Risk"],"prefix":"10.1111","volume":"170","author":[{"given":"Hans O.","family":"Kalkman","sequence":"first","affiliation":[{"name":"Child and Adolescent Psychiatry and Psychotherapy Psychiatric University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-7644","authenticated-orcid":false,"given":"Lukasz","family":"Smigielski","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry and Psychotherapy Psychiatric University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.08.002"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.03.011"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00070"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2059"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v91i9\u2010S.10112"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010231318"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2017.1414305"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15071425"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049028"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.07.012"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2009.02106.x"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307098"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.147"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.11.008"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.05.036"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005485"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893\u2010133X(99)00136\u20100"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.10.014"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2010.192252"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176042"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.03.031"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S2318"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S413101"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.171.6.502"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12458"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.04.002"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.690130"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00012"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2830\u201013.2014"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144908"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.10.050"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2019.11.005"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005716\u20100"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28903"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.7.2282"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/25152564231208250"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245252"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(98)00382\u20105"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158082"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047\u20106374(01)00246\u20109"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818809831"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651501.2019.1699575"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002484\u20105"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.008"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.09.004"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.035"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.4103\/jnrp.jnrp_425_16"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpn.JPN_1_20"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.248"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.09.001"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.07.013"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10745"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00088.2006"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn161"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.023"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.569250"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.110"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.10.009"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.264325"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990228"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.10.008"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036721"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113735"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2012.10.013"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2016.275"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.3"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.08.074"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp456"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2022.04.005"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13145"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.06.001"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.07.038"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.01.045"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109721"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327583"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201070414\u20106"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893\u2010133X(99)00030\u20105"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.113"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.12.008"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010020\u20100769\u2010x"},{"issue":"13","key":"e_1_2_15_82_1","first-page":"1765","article-title":"Pure Docosahexaenoic Acid Can Improve Depression Behaviors and Affect HPA Axis in Mice","volume":"16","author":"Jiang L.\u2010H.","year":"2012","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.861881"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyab083"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.05.020"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201004989\u20100"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.22.1046"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199411000-00001"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.05.006"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61884"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722001180"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjment\u20102024\u2010301306"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2002.00955.x"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101435"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0162-1"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.07.027"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155539"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M081877"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1717"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.10.009"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.27415"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145706006663"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415\u2010025\u201001321\u20100"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u2010978904"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.11m06879"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102298\u20102"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.843247"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010009\u20105021\u2010x"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2010.01655.x"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.030"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1637"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S340388"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2313"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.028"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pharmtox\u2010011112\u2010140320"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920007780362518"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(98)00131\u20100"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400831200"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.2183"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.12.017"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015623793"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008\u20101610"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2016.02.002"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.11.008"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101326\u20107\u201045"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309992200"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120220"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA120000628"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.04.013"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u20109081\u20107\u201022"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.041"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2023.05.009"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.18588"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.29"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u20100789\u20107"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.05.016"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.07.010"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112048"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796797"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15143731"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(01)01170\u20102"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1988"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avb.2024.101956"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004060200001"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M021782"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010023\u201000856\u2010y"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.635175"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.05.019"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.12.001"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.151"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010132543"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.04.010"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102185"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800188y"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000060"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.04.004"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.05.022"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17072393"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2023.0005"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2008.12.3923"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036052"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.32.20354"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DBP.0000267558.88457.a5"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519\u2010012\u20109569\u20103"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024\u20103205(01)01158\u20104"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112486"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20102094\u20108\u201094"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.12.005"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.06.007"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2020_163"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.05.002"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.6.1100"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.01.056"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709992029"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3564"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.648"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.07.025"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00010"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu086"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010020\u201002218\u20107"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1213011"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010018\u20101399\u20105"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.01.010"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010014\u20102010\u20103"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5343\u201008.2009"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.04.016"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1140682"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20107258(90)90064\u20109"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.04.026"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000631"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150079"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20929"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.16521"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.696655"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.02.040"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59111906"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.013"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500060\u2010JLR200"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010015\u20103919\u20109"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20105618.2006.00381.x"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u201000933\u2010z"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.08.012"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146944"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.075"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010020\u201002791\u2010x"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65192"},{"key":"e_1_2_15_207_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.9966"},{"key":"e_1_2_15_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.015"},{"key":"e_1_2_15_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2020.109975"},{"key":"e_1_2_15_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.12.030"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T06:31:51Z","timestamp":1779863511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":209,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jnc.70466"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70466","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70466"}}