{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:59:53Z","timestamp":1790323193818,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ferroptosis, an iron\u2010dependent form of regulated necrosis, is implicated in the pathogenesis of Parkinson's disease (PD). We studied the influence of energy stress on ferroptosis in differentiated dopaminergic neurons (LUHMES). Glucose deprivation conferred protection against ferroptosis induced by erastin or arachidonic acid plus iron by reducing lipid peroxidation. Glucose withdrawal did not protect against RSL3\u2010induced ferroptosis, suggesting that direct GPX4 inhibition cannot be reversed by metabolic modulation. The expression of ferroptosis markers ACSL4, GPX4, xCT, and TFRc remained unaltered during glucose deprivation. Inhibition of glycolysis using 2\u2010deoxyglucose confirmed the role of energy stress in the regulation of ferroptosis. Activation of AMP\u2010activated protein kinase (AMPK) by AICAR protected LUHMES cells from erastin\u2010induced ferroptosis, even in the presence of glucose. Conversely, AMPK expression inhibition by siRNA re\u2010sensitized cells to ferroptosis under glucose\u2010free conditions. These findings suggest that glucose metabolism and AMPK\u2010mediated energetic stress play crucial roles in regulating ferroptosis in dopaminergic neurons, with potential implications for understanding the mechanisms of neurodegeneration in PD. These findings identify a potential bioenergetic checkpoint regulating ferroptosis susceptibility under conditions of severe energy stress.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70487-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70487","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:12:24Z","timestamp":1780315944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Energy Stress\u2010Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-2553","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Jonneaux","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale Universit\u00e9 de Lille, LilNCog\u2014Lille Neuroscience &amp; Cognition, Equipe TREAT, INSERM UMRS_1172, CHU Lille, LICEND COEN Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Laine","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut de Recherche Contre le Cancer de Lille, UMR9020\u2014UMR\u2010S 1277\u2014Canther Cancer Heterogeneity, Plasticity and Therapy Resistance  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Maboudou","sequence":"additional","affiliation":[{"name":"Service de Biochimie, Centre de Biologie\u2010Pathologie CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Kluza","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut de Recherche Contre le Cancer de Lille, UMR9020\u2014UMR\u2010S 1277\u2014Canther Cancer Heterogeneity, Plasticity and Therapy Resistance  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Amandine","family":"Bonte","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale Universit\u00e9 de Lille, LilNCog\u2014Lille Neuroscience &amp; Cognition, Equipe TREAT, INSERM UMRS_1172, CHU Lille, LICEND COEN Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flore","family":"Gouel","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale Universit\u00e9 de Lille, LilNCog\u2014Lille Neuroscience &amp; Cognition, Equipe TREAT, INSERM UMRS_1172, CHU Lille, LICEND COEN Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale Universit\u00e9 de Lille, LilNCog\u2014Lille Neuroscience &amp; Cognition, Equipe TREAT, INSERM UMRS_1172, CHU Lille, LICEND COEN Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-6800","authenticated-orcid":false,"given":"Philippe","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut de Recherche Contre le Cancer de Lille, UMR9020\u2014UMR\u2010S 1277\u2014Canther Cancer Heterogeneity, Plasticity and Therapy Resistance  Lille France"},{"name":"Banque de Tissus, Centre de Biologie\u2010Pathologie CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Devedjian","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale Universit\u00e9 de Lille, LilNCog\u2014Lille Neuroscience &amp; Cognition, Equipe TREAT, INSERM UMRS_1172, CHU Lille, LICEND COEN Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25135"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.12.086"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010019\u201002473\u2010y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.12.013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.05.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2519\u201009.2009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160211"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010020\u20100461\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101890"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108767"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413413"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:11:17Z","timestamp":1790320277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jnc.70487"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70487","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70487"}}