{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:37:04Z","timestamp":1792795024752,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23bk0104126h0003"],"award-info":[{"award-number":["23bk0104126h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Parkinson's disease (PD), a prevalent neurodegenerative disorder, is characterized by progressive loss of dopaminergic neurons in the midbrain. While dopamine replacement therapy effectively manages early symptoms, its long\u2010term use leads to motor complications, highlighting the urgent need for treatments that directly address the underlying pathological changes. Cell transplantation, which aims to replace the lost dopaminergic neurons, has emerged as a promising approach. Early attempts using fetal ventral mesencephalic (fVM) tissue showed proof\u2010of\u2010concept, with some patients experiencing long\u2010term motor improvement. However, these trials have been hampered by inconsistent results, graft\u2010induced dyskinesia (GID), and significant ethical and logistical issues related to tissue supply. These challenges have shifted the focus to pluripotent stem cells (PSCs), including human\u2010induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), which offer a stable, ethically sound, and scalable source of high\u2010quality cells. Recent clinical trials using PSCs suggest a turning point. All reported clinical trials demonstrated the safety and feasibility of this approach. The need for long\u2010term safety and efficacy data, patient stratification, and techniques to improve graft survival are key areas of future research. Nevertheless, recent clinical trial successes suggest that cell transplantation is moving beyond symptomatic relief to become a truly restorative therapy for PD.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70500-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70500","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:20:34Z","timestamp":1782908434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parkinson's Disease Cell Transplantation Therapy: A New Dawn With Pluripotent Stem Cell\u2013Based Therapy"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9869-4988","authenticated-orcid":false,"given":"Etsuro","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hodaka","family":"Yamakado","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukatsu","family":"Sawamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Application Center for iPS Cell Research and Application (CiRA)  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-9640","authenticated-orcid":false,"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Kyoto University Office of Research Acceleration  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.058"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22360"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.2.0169"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70295-8"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400118"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.123"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-025-02567-2"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0507-2"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90692-7"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-179002"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/096368970000900205"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1529"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.09.010"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00894"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0016-3"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17165-w"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.01.013"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181474"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441002"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.01.010"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp328"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.8.741"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00518"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23664"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01422-3"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.12.005"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1747"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130303"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321702"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-2011-11004"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(10)84015-4"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1746"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23012"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605245113"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2105529"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520420033021"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.066811"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2017.0066"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24668"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15970-w"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2025.07.012"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1591"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10720"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06300-4"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23743"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-024-02813-y"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.350193"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0352-8"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae303"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08700-0"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915872"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00405-2"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08845-y"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2025.107833"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2020.06.002"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2401857"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad265"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:29:15Z","timestamp":1790148555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jnc.70500"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70500","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.70500\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70500\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.70500\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70500"}}