{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:13:28Z","timestamp":1790324008092,"version":"4.1.0"},"reference-count":127,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PICT 2018\u201000517"],"award-info":[{"award-number":["PICT 2018\u201000517"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Recently, Japan conditionally approved the first cell transplantation therapy for a central nervous system disorder using induced pluripotent stem cells as the source of dopaminergic progenitors to treat Parkinson's disease. This milestone was achieved almost 40\u2009years after the first cell therapy trial for Parkinson's disease in Lund, Sweden, and 18\u2009years after the first clinical trial using oligodendrocyte progenitors derived from pluripotent stem cells for spinal cord injury. In this review, we update the current state of development of cell therapies based on pluripotent stem cells for diseases of the central nervous system and discuss the potential effects of neuroinflammation on these cell therapies. Focusing on Parkinson's disease, we summarize data showing the functional relevance of tumor necrosis factor\u2010alpha for the differentiation and viability of pluripotent stem cell\u2010derived dopaminergic progenitors and its dual effects on endogenous dopaminergic neurons, as presented at the Second Meeting of the Latin American Glia Club, held April 7\u20139, 2025, in Buenos Aires, Argentina. In addition, we propose areas of cell transplantation in Parkinson's disease in which research efforts could be focused and present a cautionary note on the use of non\u2010selective anti\u2010tumor necrosis factor\u2010\u03b1 therapies alongside pluripotent stem cell\u2010derived dopaminergic progenitor transplantation. Finally, we provide an in\u2010depth list of TNF receptor agonists and antagonists and specific TNF\u2010mediated cell\u2010death inhibitors and discuss their properties as possible candidates for increasing dopaminergic progenitor survival after transplantation in patients with Parkinson's disease.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70540-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70540","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:47:02Z","timestamp":1788335222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroinflammation and Graft Survival in Pluripotent Stem Cell\u2010Derived Therapies for the Central Nervous System"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3209-1263","authenticated-orcid":false,"given":"Luc\u00eda","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir\u2014IIBBA\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candela Magal\u00ed","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir\u2014IIBBA\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-9726","authenticated-orcid":false,"given":"Fernando J.","family":"Pitossi","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir\u2014IIBBA\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"3","key":"e_1_2_18_2_1","first-page":"255","article-title":"Protective Effects of PJ34, A Novel, Potent Inhibitor of Poly(ADP\u2010Ribose) Polymerase (PARP) in In\u00a0Vitro and In\u00a0Vivo Models Of Stroke","volume":"7","author":"Abdelkarim G. E.","year":"2001","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000548021"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606526103"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1814"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci16050461"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70295\u20108"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010323\u201085555\u20106.00012\u20106"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400118"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12570"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13748"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3834"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.08.011"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/cns.12.13"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1670650"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14151148"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.171"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1209188"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.11.010"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010016\u20100708\u20102"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061628"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1178662"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.11.018"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.83"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2003.03014.x"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5593"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101235\u20100"},{"key":"e_1_2_18_28_1","volume-title":"Jasper's Basic Mechanisms of the Epilepsies","author":"Dingledine R.","year":"2024"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101263"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605195113"},{"key":"e_1_2_18_32_1","volume-title":"Adalimumab","author":"Ellis C. R.","year":"2026"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00072-6"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.06.013"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.5.SPINE22167"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00401"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/610813"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027621"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-j0001.2002"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115632"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.12.010"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647\u2010199812000\u201000001"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010018\u20100630\u20107"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201003903\u20103"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90192-2"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)01050-X"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa104"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.024"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26865"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010014\u20100329\u20103"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u20100669\u20106"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.102"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00420-4"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.01.002"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.4137\/JCD.S23844"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.030"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.12.005"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810083391506"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810153391607"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00053"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006122\u20100"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220403"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00237-9"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704549"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.10.021"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311766200"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210108"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2009.06548.x"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1504-06.2006"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20102094\u20105\u201045"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(03)00521\u2010x"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010020\u201000564\u20103"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00509"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09852"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010019\u20100408\u20104"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201137119"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.163"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527\u20103466.2007.00018.x"},{"key":"e_1_2_18_80_1","volume-title":"Etanercept","author":"Pan A.","year":"2026"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.751021"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14109"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14191"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002785\u2010y"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2004.01.004"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.02.018"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn101"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.11.005"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.02.007"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2025.08.012"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat2738"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2018.1524664"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008700\u20100"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.08.012"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.02.004"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm15093254"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010011\u20100064\u2010y"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04264.x"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13973"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.031"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.916719"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008845\u2010y"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.176"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90222-C"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.457"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1334847"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.10.001"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010026\u201002492\u20109"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010021\u201002711\u20104"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.6.1531"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.888274"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.28400"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00091"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1596484"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137267"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2025.102507"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.07.023"},{"key":"e_1_2_18_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263021"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.06.054"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41434\u2010019\u20100077\u20104"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031957\u20107"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090117"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116174"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556\u2010026\u201000420\u20109"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072221"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.6.13583"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201005308\u20103"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.70540","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.70540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:55:56Z","timestamp":1790322956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.70540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":127,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jnc.70540"],"URL":"https:\/\/doi.org\/10.1111\/jnc.70540","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70540"}}