{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:56:42Z","timestamp":1790945802060,"version":"4.1.0"},"reference-count":124,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG073823"],"award-info":[{"award-number":["R01 AG073823"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG082388"],"award-info":[{"award-number":["RF1 AG082388"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) involves early synaptic vulnerability and systemic metabolic dysfunction, yet the impact of peripheral metabolic state on brain function remains unclear. Previous studies indicate a link between AMP\u2010activated protein kinase (AMPK) signaling dysregulation and AD pathophysiology. Here we tested whether systemic treatment of a potent pan\u2010AMPK activator MK\u20108722 influences cognitive function, synaptic plasticity, and circulating metabolic profiles in APP\/PS1 AD model mice at the age of 6\u20138\u2009months. MK\u20108722 was well tolerated and activated AMPK in the liver but not in the hippocampus. Our findings revealed that MK\u20108722 selectively improved AD\u2010associated hippocampal\u2010dependent spatial memory deficits and enhanced dendritic spine maturation in the hippocampus of APP\/PS1 mice. In contrast, MK\u20108722 did not alter hippocampal long\u2010term potentiation (LTP). In\u2010depth analysis of plasma lipidomics and metabolomics revealed coordinated disruptions in glycerophosphatidylcholine species, glutathione cycling, carnitine\u2010dependent fatty acid transport, and the kynurenine pathway in APP\/PS1 mice, which were partially normalized by MK\u20108722 treatment. These findings suggest that peripheral AMPK activation can remodel systemic metabolic networks and improve certain aspects of cognitive and synaptic outcomes in early AD, supporting a model in which metabolic interventions outside the brain influence neuronal resilience.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70563-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70563","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:32:43Z","timestamp":1790944363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>AMPK<\/scp>\n                    Activator\n                    <scp>MK<\/scp>\n                    \u20108722 Improves Spatial Memory Deficit and Alters Metabolome in\n                    <scp>APP<\/scp>\n                    \/\n                    <scp>PS1 AD<\/scp>\n                    Mouse Model"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-4314","authenticated-orcid":false,"given":"Noelle I.","family":"Nicol","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0550-6269","authenticated-orcid":false,"given":"Erin","family":"Dunlap","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Jester","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-4180","authenticated-orcid":false,"given":"Nathaniel A.","family":"Swift","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-447X","authenticated-orcid":false,"given":"Ethan","family":"Underwood","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2010Section on Molecular Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2010Section on Molecular Medicine Wake Forest University School of Medicine  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S.","year":"2021","journal-title":"Nature Neuroscience"},{"key":"e_1_2_13_45_1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nn.4017","article-title":"The Case for Rejecting the Amyloid Cascade Hypothesis","volume":"18","author":"Herrup K.","year":"2015","journal-title":"Nature Neuroscience"},{"key":"e_1_2_13_46_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197003","article-title":"Recognition of Early Stage Thigmotaxis in Morris Water Maze Test With Convolutional Neural Network","volume":"13","author":"Higaki A.","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_13_47_1","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1523\/JNEUROSCI.21-19-07463.2001","article-title":"The Brain Metabolite Kynurenic Acid Inhibits alpha7 Nicotinic Receptor Activity and Increases Non\u2010alpha7 Nicotinic Receptor Expression: Physiopathological Implications","volume":"21","author":"Hilmas C.","year":"2001","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_13_48_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbrc.2020.11.119","article-title":"Structurally Different Lysophosphatidylethanolamine Species Stimulate Neurite Outgrowth in Cultured Cortical Neurons via Distinct G\u2010Protein\u2010Coupled Receptors and Signaling Cascades","volume":"534","author":"Hisano K.","year":"2021","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"e_1_2_13_49_1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer's Disease: The Challenge of the Second Century","volume":"3","author":"Holtzman D. 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