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Although sensory neuron subtypes differ in function and transcriptional profiles, whether these neurons also differ in axonal microtubule properties remains unclear. Here, we asked whether distinct DRG neuronal subtypes exhibit subtype\u2010specific axonal tubulin post\u2010translational modifications (PTMs), which have been implicated in regulating microtubule structure and function. Using established markers, we resolved five major sensory neuronal subtypes in primary cultures of adult mouse DRG neurons: parvalbumin\u2010positive (PV\n                    <jats:sup>+<\/jats:sup>\n                    ) proprioceptors, A\u03b2 low\u2010threshold mechanoreceptors (LTMRs), calcitonin gene\u2010related peptide\u2010positive (CGRP\n                    <jats:sup>+<\/jats:sup>\n                    ) peptidergic nociceptors, isolectin B4\u2010positive (IB4\n                    <jats:sup>+<\/jats:sup>\n                    ) non\u2010peptidergic nociceptors, and tyrosine hydroxylase\u2010positive (TH\n                    <jats:sup>+<\/jats:sup>\n                    ) C\u2010LTMRs. Axons exhibited subtype\u2010specific differences in \u03b2III\u2010tubulin content and distinct tubulin PTM signatures, which were validated in\u00a0vivo\n                    <jats:italic>.<\/jats:italic>\n                    CGRP\n                    <jats:sup>+<\/jats:sup>\n                    and IB4\n                    <jats:sup>+<\/jats:sup>\n                    neurons displayed lower levels of tubulin acetylation and glutamylation compared to PV\n                    <jats:sup>+<\/jats:sup>\n                    neurons and LTMRs in both culture and tissue, and nociceptor neurons showed greater susceptibility to nocodazole\u2010induced microtubule destabilization compared to PV\n                    <jats:sup>+<\/jats:sup>\n                    neurons. Inhibition of histone deacetylase 6 conferred nocodazole resistance to both CGRP\n                    <jats:sup>+<\/jats:sup>\n                    and IB4\n                    <jats:sup>+<\/jats:sup>\n                    neurons. Together, these findings suggest that distinct tubulin PTM signatures contribute to axonal stability and vulnerability across sensory neuron subtypes and support the use of primary adult DRG neuron culture as a tractable platform for biochemical and functional dissection of sensory neuron populations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc70564-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.70564","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:18:04Z","timestamp":1791289084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subtype\u2010Specific Tubulin Post\u2010Translational Modification Profiles Predict Differential Axonal Stability in\n                    <scp>DRG<\/scp>\n                    Neurons"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4108-7089","authenticated-orcid":false,"given":"Gil","family":"Song","sequence":"first","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"},{"name":"BK21 Four Future Veterinary Medicine Leading Education &amp; Research Center, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-0286","authenticated-orcid":false,"given":"Eun Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"},{"name":"BK21 Four Future Veterinary Medicine Leading Education &amp; Research Center, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2794-0383","authenticated-orcid":false,"given":"Harryn","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"},{"name":"BK21 Four Future Veterinary Medicine Leading Education &amp; Research Center, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1158-1992","authenticated-orcid":false,"given":"Eun\u2010Hae","family":"Jang","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"},{"name":"Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"},{"name":"Comparative Medicine Disease Research Center Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5316-7098","authenticated-orcid":false,"given":"Jaeyong","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9148-4824","authenticated-orcid":false,"given":"Hyuk\u2010Joo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-4297","authenticated-orcid":false,"given":"Eun\u2010Mi","family":"Hur","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"},{"name":"BK21 Four Future Veterinary Medicine Leading Education &amp; 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