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In the present study, <jats:italic>in vivo<\/jats:italic> experiments using a non\u2010invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation. Corticosterone treatment induced an increased expression of stress\u2010activated c\u2010Jun N\u2010terminal kinase (<jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>) in the hippocampus, accompanied by decreases in glycogen synthase kinase 3\u03b2, increases in <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>au levels and increased neuronal cell death (caspase\u20103 activity). All these effects were reversed by the administration of a <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>1 inhibitor or by the mineralocorticoid receptor antagonist spironolactone. It is suggested that the mineralocorticoid receptors and <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\u2010mediated pathways are involved in the interaction of glucocorticoid\u2010insulin resistance and the development of relevant cellular processes for Alzheimer\u2032s disease<\/jats:p>","DOI":"10.1111\/jne.12006","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T06:24:20Z","timestamp":1353997460000},"page":"350-356","source":"Crossref","is-referenced-by-count":30,"title":["Mineralocorticoid Receptor Activation Induces Insulin Resistance Through c\u2010Jun N\u2010terminal kinases in Response to Chronic Corticosterone: Cognitive Implications"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Solas","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gerenu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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