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To further understand the functions of gG<\/jats:styled-content>nIH<\/jats:styled-content>, we examined its interactions with two native goldfish gonadotrophin\u2010releasing hormones, salmon gonadotrophin\u2010releasing hormone (sG<\/jats:styled-content>nRH)<\/jats:styled-content> and chicken (c)G<\/jats:styled-content>nRH<\/jats:styled-content>\u2010II in vivo<\/jats:italic> and in vitro<\/jats:italic>. Intraperitoneal injections of gG<\/jats:styled-content>nIH<\/jats:styled-content> alone reduced serum LH<\/jats:styled-content> levels in fish in early and mid gonadal recrudescence; this inhibition was also seen in fish co\u2010injected with either sG<\/jats:styled-content>nRH<\/jats:styled-content> or cG<\/jats:styled-content>nRH<\/jats:styled-content>\u2010II during early recrudescence. Injection of gG<\/jats:styled-content>nIH<\/jats:styled-content> alone elevated pituitary LH<\/jats:styled-content>\u2010\u03b2 and FSH<\/jats:styled-content>\u2010\u03b2 mRNA<\/jats:styled-content> levels at early and mid recrudescence, and FSH<\/jats:styled-content>\u2010\u03b2 mRNA<\/jats:styled-content> at late recrudescence. Co\u2010injection of gG<\/jats:styled-content>nIH<\/jats:styled-content> attenuated the stimulatory influences of sG<\/jats:styled-content>nRH<\/jats:styled-content> on LH<\/jats:styled-content>\u2010\u03b2 in early recrudescence, and LH<\/jats:styled-content>\u2010\u03b2 and FSH<\/jats:styled-content>\u2010\u03b2 mRNA<\/jats:styled-content> levels in mid and late recrudescence, as well as the cG<\/jats:styled-content>nRH<\/jats:styled-content>\u2010II\u2010elicited increase in LH<\/jats:styled-content>\u2010\u03b2, but not FSH<\/jats:styled-content>\u2010\u03b2, mRNA<\/jats:styled-content> expression at mid and late recrudescence. sG<\/jats:styled-content>nRH<\/jats:styled-content> and cG<\/jats:styled-content>nRH<\/jats:styled-content>\u2010II injection increased pituitary gG<\/jats:styled-content>nIH<\/jats:styled-content>\u2010R mRNA<\/jats:styled-content> expression in mid and late recrudescence but gG<\/jats:styled-content>nIH<\/jats:styled-content> reduced gG<\/jats:styled-content>nIH<\/jats:styled-content>\u2010R mRNA<\/jats:styled-content> levels in late recrudescence. gG<\/jats:styled-content>nIH<\/jats:styled-content> did not affect basal LH<\/jats:styled-content> release from perifused pituitary cells and continual exposure to gG<\/jats:styled-content>nIH<\/jats:styled-content> did not alter the LH<\/jats:styled-content> responses to acute applications of G<\/jats:styled-content>nRH<\/jats:styled-content>. However, a short 5\u2010min G<\/jats:styled-content>nIH<\/jats:styled-content> treatment in the middle of a 60\u2010min G<\/jats:styled-content>nRH<\/jats:styled-content> perifusion selectively reduced the cG<\/jats:styled-content>nRH<\/jats:styled-content>\u2010II\u2010induced release of LH<\/jats:styled-content>. These novel results indicate that, in goldfish, gG<\/jats:styled-content>nIH<\/jats:styled-content> and G<\/jats:styled-content>nRH<\/jats:styled-content> modulate pituitary G<\/jats:styled-content>nIH<\/jats:styled-content>\u2010R<\/jats:styled-content> expression and gG<\/jats:styled-content>nIH<\/jats:styled-content> differentially affects sG<\/jats:styled-content>nRH<\/jats:styled-content> and cG<\/jats:styled-content>nRH<\/jats:styled-content>\u2010II regulation of LH<\/jats:styled-content> secretion and gonadotrophin subunit mRNA<\/jats:styled-content> levels. Furthermore, these actions are manifested in a reproductive stage\u2010dependent manner.<\/jats:p>","DOI":"10.1111\/jne.12024","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T20:43:02Z","timestamp":1358455382000},"page":"506-516","source":"Crossref","is-referenced-by-count":80,"title":["Seasonal Effect of Gonadotrophin Inhibitory Hormone on Gonadotrophin\u2010Releasing Hormone<\/scp>\u2010induced Gonadotroph Functions in the Goldfish Pituitary"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Moussavi","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Calgary Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wlasichuk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Calgary Calgary Canada"},{"name":"Department of Biological Sciences University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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