{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:27:44Z","timestamp":1759692464531},"reference-count":68,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ghent University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Mounting magnetic resonance imaging (MRI) research is characterising the neurobiological trajectories of healthy human brain development. In parallel, studies increasingly acknowledge the relevance of perturbations of these trajectories for adolescent and adult psychopathology. Although an influence of steroid hormones on mood and anxiety disorders has been demonstrated in adults, very little is known about how steroid hormones alter human brain development and contribute to adolescent psychopathology. This review focuses on recent evidence obtained from structural and functional MRI in children and adolescents with genetic endocrine disorders and with characteristic fluctuations in androgen or oestrogen levels (<jats:styled-content style=\"fixed-case\">f<\/jats:styled-content>amilial <jats:styled-content style=\"fixed-case\">m<\/jats:styled-content>ale <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>recocious <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>uberty, <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>ongenital <jats:styled-content style=\"fixed-case\">a<\/jats:styled-content>drenal <jats:styled-content style=\"fixed-case\">h<\/jats:styled-content>yperplasia, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>linefelter syndrome and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urner syndrome). It aims to highlight how neurobiological findings from these paediatric endocrine disorders can provide insight into the contribution of sex steroids with respect to the development of neurocircuitry involved in affective processing (amygdala, hippocampus) and cognitive control (prefrontal cortex, inferior frontal gyrus, striatum). In addition, findings from these populations may also provide important information on aberrant psychological processes relevant for the clinical care and management of these populations. Finally, the findings are discussed within the context of current frameworks in animal models, such as the organisational\u2013activational hypothesis or the aromatisation hypothesis. The review ends with a discussion of open questions for future enquiry with the goal of integrating translational models with current knowledge of endocrine disorders and developmental studies in healthy populations.<\/jats:p>","DOI":"10.1111\/jne.12048","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T06:38:54Z","timestamp":1368081534000},"page":"762-770","source":"Crossref","is-referenced-by-count":15,"title":["Magnetic Resonance Imaging in Paediatric Psychoneuroendocrinology: A New Frontier for Understanding the Impact of Hormones on Emotion and Cognition"],"prefix":"10.1111","volume":"25","author":[{"given":"S. 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