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Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. Although it has long been known that the activity of\n                    <jats:styled-content style=\"fixed-case\">MNC<\/jats:styled-content>\n                    s depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the\n                    <jats:styled-content style=\"fixed-case\">MNC<\/jats:styled-content>\n                    s themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin\n                    <jats:styled-content style=\"fixed-case\">MNC<\/jats:styled-content>\n                    activity.\n                  <\/jats:p>","DOI":"10.1111\/jne.12051","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T11:55:28Z","timestamp":1369310128000},"page":"678-710","source":"Crossref","is-referenced-by-count":165,"title":["Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms"],"prefix":"10.1111","volume":"25","author":[{"given":"C. H.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Physiology and Centre for Neuroendocrinology University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Bains","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Hotchkiss Brain Institute University of Calgary Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Centre for Integrative Physiology University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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