{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:55:11Z","timestamp":1760385311668,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research","award":["06454019","21380184"],"award-info":[{"award-number":["06454019","21380184"]}]},{"name":"High-Tech Research Center"},{"DOI":"10.13039\/100014424","name":"Meiji University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014424","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>We recently reported that the quantitative and qualitative transition of stem\/progenitor cells occurs by the acquisition of a novel mechanism in the terminal differentiation during postnatal development of the anterior pituitary. We hypothesised that this novel mechanism is an alteration of a cell supply system accompanying proliferation of the progenitor cells. In the present study, we examined the proliferation activities of progenitor cells by indication of the expression of <jats:italic>Nestin<\/jats:italic>, a marker of rapidly dividing progenitor cells, aiming to verify our hypothesis and to resolve another outstanding issue regarding whether the <jats:italic>Nestin<\/jats:italic> gene is expressed in the pituitary. We found that <jats:styled-content style=\"fixed-case\">NESTIN<\/jats:styled-content>\u2010positive dividing cells certainly exist in the pituitary through all stages of development. Almost all of the <jats:styled-content style=\"fixed-case\">PROP<\/jats:styled-content>1\u2010positive progenitor cells express <jats:italic>Nestin<\/jats:italic> in early embryonic pituitary development. Thereafter, <jats:italic>Nestin<\/jats:italic>\u2010expressing dividing cells involved in the cell supply system transfer from <jats:styled-content style=\"fixed-case\">PROP<\/jats:styled-content>1\u2010positive progenitor cells to committed progenitor cells, such as <jats:styled-content style=\"fixed-case\">PIT<\/jats:styled-content>1\u2010positive cells, on neonatal pituitary development. Furthermore, our data, together with the findings of previous studies on cell lineage tracing analyses using <jats:italic>Nestin<\/jats:italic>\u2010Cre mice derived by the central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>)\u2010specific <jats:italic>Nestin<\/jats:italic> promoter, suggest that at least two regulation systems for <jats:italic>Nestin<\/jats:italic>\u2010expression exist in the pituitary, with the majority of these not being <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\u2010specific.<\/jats:p>","DOI":"10.1111\/jne.12077","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T13:34:37Z","timestamp":1373895277000},"page":"779-791","source":"Crossref","is-referenced-by-count":22,"title":["Rapid Transition of <scp>NESTIN<\/scp>\u2010Expressing Dividing Cells from <scp>PROP<\/scp>1\u2010Positive to <scp>PIT<\/scp>1\u2010Positive Advances Prenatal Pituitary Development"],"prefix":"10.1111","volume":"25","author":[{"given":"S.","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Life Science Graduate School of Agriculture Meiji University Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kato","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Endocrinology Meiji University Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Endocrinology Meiji University Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yako","sequence":"additional","affiliation":[{"name":"Division of Life Science Graduate School of Agriculture Meiji University Kanagawa 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