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Oestradiol membrane signalling involves the transactivation of metabotrophic glutamate receptors (mGluRs) that transduce steroid information through <jats:styled-content style=\"fixed-case\">protein kinase C<\/jats:styled-content> signalling cascades producing rapid activation of lordosis\u2010regulating circuits. It has been known for some time that oestradiol initially produces an inhibition of the medial preoptic nucleus. We have demonstrated that underlying this inhibition is oestradiol acting in the arcuate nucleus to induce \u03b2\u2010endorphin release, which inhibits the <jats:styled-content style=\"fixed-case\">medial preoptic nucleus<\/jats:styled-content> through a \u03bc\u2010opioid receptor mechanism. This transient inhibition is relieved by either subsequent progesterone treatment or longer exposure to higher doses of oestradiol to facilitate lordosis behaviour. We review recent findings about oestradiol membrane signalling inducing dendritic spine formation in the arcuate nucleus that is critical for oestradiol induction of sexual receptivity. Moreover, we discuss the evidence that, in addition to <jats:styled-content style=\"fixed-case\">oestrogen receptor <\/jats:styled-content>\u03b1, several other putative membrane oestrogen receptors facilitate lordosis behaviour through regulation of the arcuate nucleus. These include the <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>30 and the <jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content> activated <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>q\u2010m<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>. Finally, we report on the importance of <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> acting at <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content><jats:sub>B<\/jats:sub> receptors for oestradiol membrane signalling that regulates lordosis circuit activation and sexual receptivity.<\/jats:p>","DOI":"10.1111\/jne.12103","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T15:36:57Z","timestamp":1379000217000},"page":"1012-1023","source":"Crossref","is-referenced-by-count":27,"title":["Temporal and Concentration\u2010Dependent Effects of Oestradiol on Neural Pathways Mediating Sexual Receptivity"],"prefix":"10.1111","volume":"25","author":[{"given":"P.","family":"Micevych","sequence":"first","affiliation":[{"name":"Department of Neurobiology David Geffen School of Medicine at UCLA Laboratory of Neuroendocrinology Brain Research Institute University of California Los Angeles CA 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