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Because a decrease in appetite is a general response to stress in fish and other vertebrates, we investigated the role of AVT as a possible food intake regulator in fish. We used i.c.v. injections for central administration of AVT to rainbow trout (<jats:italic>Oncorhynchus mykiss<\/jats:italic>). In a first experiment, we evaluated the temporal response of food intake after AVT treatment. In a second experiment, we investigated the effects of central AVT administration on the response of typical stress markers (plasma cortisol, glucose and lactate), as well as brain serotonergic, noradrenergic and dopaminergic activity. In addition, the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of genes involved in food intake regulation [neuropetide Y, pro\u2010opiomelanocortin (POMC), cocaine\u2010 and amphetamine\u2010regulated transcript (CART) and corticotrophin\u2010releasing factor (CRF)] and in CRF\u2010 (CRF\u2010binding protein) and AVT\u2010signalling (pro\u2010VT and AVT receptor), were also assessed after AVT treatment. Our results showed that AVT is a potent anorexigenic factor in fish. Increases of plasma cortisol and glucose after AVT treatment strongly suggest that AVT administration induced a stress response and that AVT action was mediated by hypothalamic\u2010pituitary\u2010interrenal axis activation, which was also supported by the increase of the serotonergic activity in trout telencephalon and hypothalamus. The increased hypothalamic levels of POMC and CART suggest that these peptides might have a role in the anorexigenic action of AVT, whereas the involvement of CRF signalling is unclear.<\/jats:p>","DOI":"10.1111\/jne.12126","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T17:09:52Z","timestamp":1387213792000},"page":"89-99","source":"Crossref","is-referenced-by-count":51,"title":["Arginine Vasotocin Treatment Induces a Stress Response and Exerts a Potent Anorexigenic Effect in Rainbow Trout, <i>Oncorhynchus mykiss<\/i>"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"Gesto","sequence":"first","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda animal Departamento de Biolog\u00eda Funcional y CC. de la Salud Facultad de Biolog\u00eda Universidade de Vigo Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Soengas","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda animal Departamento de Biolog\u00eda Funcional y CC. de la Salud Facultad de Biolog\u00eda Universidade de Vigo Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rodr\u00edguez\u2010Illamola","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda animal Departamento de Biolog\u00eda Funcional y CC. de la Salud Facultad de Biolog\u00eda Universidade de Vigo Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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