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The brain plays a central role in the counter\u2010regulatory response by eliciting parasympathetic and sympathetic hormone responses to restore normoglycaemia. Brain glucose concentrations, being approximately 15\u201320% of the blood glucose concentration in humans, are rigorously maintained during hypoglycaemia through adaptions such as increased cerebral glucose transport, decreased cerebral glucose utilisation and, possibly, by using<jats:styled-content style=\"fixed-case\">central nervous system<\/jats:styled-content>glycogen as a glucose reserve. However, during sustained hypoglycaemia, the brain cannot maintain a sufficient glucose influx and, as the cerebral hypoglycaemia becomes severe,<jats:styled-content style=\"fixed-case\">electroencephalogram<\/jats:styled-content>changes, oxidative stress and regional neuronal death ensues. With particular focus on evidence from experimental studies on nondiabetic<jats:styled-content style=\"fixed-case\">IIH<\/jats:styled-content>, this review outlines the central mechanisms behind the counter\u2010regulatory response to<jats:styled-content style=\"fixed-case\">IIH<\/jats:styled-content>, as well as cerebral adaption to avoid sequelae of cerebral neuroglycopaenia, including seizures and coma.<\/jats:p>","DOI":"10.1111\/jne.12133","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T14:08:38Z","timestamp":1389794918000},"page":"123-150","source":"Crossref","is-referenced-by-count":34,"title":["Effect of Insulin\u2010Induced Hypoglycaemia on the<scp>Central Nervous System<\/scp>: Evidence from Experimental Studies"],"prefix":"10.1111","volume":"26","author":[{"given":"V. F. 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