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This organisation is provided at the cellular level by the molecular clock, a macromolecular transcription\u2010based oscillator formed by the clock and the clock\u2010controlled genes that is present in both central and peripheral tissues. In mammals, melanopsin in light\u2010sensitive retinal ganglion cells plays a considerable role in the synchronisation of the circadian timing system to the daily light\/dark cycle. Melatonin, a hormone synthesised in the pineal gland exclusively at night and an output of the central clock, has a fundamental role in regulating\/timing several physiological functions, including glucose homeostasis, insulin secretion and energy metabolism. As such, metabolism is severely impaired after a reduction in melatonin production. Furthermore, light pollution during the night and shift work schedules can abrogate melatonin synthesis and impair homeostasis. 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