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Adverse early\u2010life experiences, such as stress exposure or suboptimal maternal care, can have long\u2010lasting detrimental consequences for an individual. This phenomenon is often referred to as \u2018early\u2010life programming\u2019 and is associated with an increased risk of disease. Typically, rodents exposed to prenatal stress or postnatal maternal deprivation display enhanced neuroendocrine responses to stress, increased levels of anxiety and depressive\u2010like behaviours, and cognitive impairments. Some of the phenotypes observed in these models of early\u2010life adversity are likely to share common neurobiological mechanisms. For example, there is evidence for impaired glucocorticoid negative\u2010feedback control of the\n                    <jats:styled-content style=\"fixed-case\">hypothalamic\u2010pituitary\u2010adrenal<\/jats:styled-content>\n                    axis, altered glutamate neurotransmission and reduced hippocampal neurogenesis in both prenatally stressed rats and rats that experienced deficient maternal care. The possible mechanisms through which maternal stress during pregnancy may be transmitted to the offspring are reviewed, with special consideration given to altered maternal behaviour postpartum. We also discuss what is known about the neurobiological and epigenetic mechanisms that underpin early\u2010life programming of the neonatal brain in the first generation and subsequent generations, with a view to abrogating programming effects and potentially identifying new therapeutic targets for the treatment of stress\u2010related disorders and cognitive impairment.\n                  <\/jats:p>","DOI":"10.1111\/jne.12175","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T14:23:11Z","timestamp":1405434191000},"page":"707-723","source":"Crossref","is-referenced-by-count":340,"title":["The Consequences of Early\u2010Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations"],"prefix":"10.1111","volume":"26","author":[{"given":"S.","family":"Maccari","sequence":"first","affiliation":[{"name":"LIA International Laboratory Associated UMR 8576 CNRS Neural plasticity Team University of Lille 1 France and Sapienza University of Rome IRCCS NEUROMED Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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