{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:05:35Z","timestamp":1763183135365,"version":"3.37.3"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T00:00:00Z","timestamp":1419120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports and Culture of Japan","doi-asserted-by":"crossref","award":["20791144"],"award-info":[{"award-number":["20791144"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Pituitary adenylate cyclase\u2010activating polypeptide (<jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content>) was originally identified as a hypothalamic activator of cyclic adenosine monophosphate production in pituitary cells. <jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content> and its receptor are expressed not only in the central nervous system, but also in peripheral organs, and function to stimulate pituitary hormone synthesis and secretion as both a hypothalamic\u2010pituitary\u2010releasing factor and an autocrine\u2010paracrine factor within the pituitary. <jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content> stimulates the expression of the gonadotrophin \u03b1, luteinising hormone (<jats:styled-content style=\"fixed-case\">LH) <\/jats:styled-content>\u03b2 and follicle\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">FSH) <\/jats:styled-content>\u03b2 subunits, as well as the gonadotrophin\u2010releasing hormone (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) receptor and its own <jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content> type I receptor (<jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>1R) in gonadotrophin\u2010secreting pituitary cells. In turn, Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>, which is known to be a crucial component of gonadotrophin secretion, stimulates the expression of <jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>1R in gonadotrophs. In addition, <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>1R and <jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content> modulate the functions of Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010producing neurones in the hypothalamus. This review summarises the current understanding of the possible roles of <jats:styled-content style=\"fixed-case\">PACAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>1R in modulating hypothalamus and pituitary neuroendocrine cells in the mouse models.<\/jats:p>","DOI":"10.1111\/jne.12230","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T02:02:22Z","timestamp":1412906542000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Role of Pituitary Adenylate Cyclase\u2010Activating Polypeptide in Modulating Hypothalamus\u2010Pituitary Neuroendocrine Functions in Mouse Cell Models"],"prefix":"10.1111","volume":"27","author":[{"given":"H.","family":"Kanasaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shimane University School of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oride","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shimane University School of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kyo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shimane University School of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-11-1-177"},{"key":"e_1_2_10_3_1","first-page":"31","article-title":"GnRH pulses\u2013the regulators of human reproduction","volume":"104","author":"Marshall JC","year":"1993","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91757-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.6.619"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001370"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.1.211"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(93)90035-F"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1016\/S0021-9258(17)37514-2","article-title":"Pituitary adenylate cyclase\u2010activating polypeptide increases [Ca2]i in rat gonadotrophs through an inositol trisphosphate\u2010dependent mechanism","volume":"269","author":"Rawlings SR","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4179(97)90064-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1440215"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/gye.15.3.184.191"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00169-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.09.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb07004.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1115"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-1-264"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(94)00099-J"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000125864"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(91)90018-K"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.142R001"},{"key":"e_1_2_10_22_1","first-page":"473","article-title":"The physiology of gonadotropin\u2010releasing hormone (GnRH) secretion in men and women","volume":"41","author":"Crowley WF","year":"1985","journal-title":"Recent Prog Horm Res"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(98)00049-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00082-6"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1210\/endo.137.11.8895347","article-title":"Transient periovulatory expression of pituitary adenylate cyclase activating peptide in rat ovarian cells","volume":"137","author":"Gras S","year":"1996","journal-title":"Endocrinology"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.3.818"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.3.1158"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0131"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11222.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.5.1703"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00186-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:20:2:141"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.04.021"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.3.826"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(96)00051-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1340033"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00047-A"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.060327"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.07.005"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/endo.139.4.5937","article-title":"Mechanism of action of pituitary adenylate cyclase\u2010activating polypeptide on human glycoprotein hormone alpha\u2010subunit transcription in alphaT3\u20101 gonadotropes","volume":"139","author":"Burrin JM","year":"1998","journal-title":"Endocrinology"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221140"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.1.46"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1317"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100563200"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.074765"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2011.02.010"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00109-0"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0477"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2010.05.012"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1210\/edrv-15-4-462","article-title":"Gonadotropin\u2010releasing hormone receptors: structure and signal transduction pathways","volume":"15","author":"Stojilkovic SS","year":"1994","journal-title":"Endocr Rev"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/endo.137.1.8536629","article-title":"Stimulation of mitogen\u2010activated protein kinase by gonadotropin\u2010releasing hormone: evidence for the involvement of protein kinase C","volume":"137","author":"Sundaresan S","year":"1996","journal-title":"Endocrinology"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0504"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.134.1.315"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203763200"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-2-376"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-1-509"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-10-1444"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1418"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.12.3.0070"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.110.088526"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1483"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.132662"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-0032"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1281"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1168"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.08.015"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.05.135"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.26.12280"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.9.3667"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.02.030"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.8.3424"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(96)00086-1"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.39.153"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1997.00580.x"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1997.00663.x"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2013.07.013"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01731.x"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2013.09.002"},{"key":"e_1_2_10_79_1","first-page":"239","article-title":"PACAP participates in the regulation of the hormonal events preceeding the ovulation","volume":"47","author":"Koves K","year":"1996","journal-title":"Acta Biol Hung"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb07005.x"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00116-9"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010014\u20100294\u20107"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjne.12230","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjne.12230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:13:56Z","timestamp":1696169636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.12230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,21]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jne.12230"],"URL":"https:\/\/doi.org\/10.1111\/jne.12230","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"type":"print","value":"0953-8194"},{"type":"electronic","value":"1365-2826"}],"subject":[],"published":{"date-parts":[[2014,12,21]]}}}