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In this regard, comparisons of the mechanisms underlying basal and regulated <jats:italic>Gnrhr<\/jats:italic> expression have revealed some features that promote stable and consistent <jats:italic>Gnrhr<\/jats:italic> expression in pituitary gonadotroph cells in different species. The presence of two divergent <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>1 (<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>5A1) response elements in all analysed mammalian <jats:italic>Gnrhr<\/jats:italic> promoters probably comprises one of the features that ensures reliable expression in the pituitary. By contrast, in other tissues, such as the hippocampus and testis, our analyses revealed dissimilar levels of <jats:italic>Gnrhr<\/jats:italic> expression among species. Indeed, <jats:italic>Gnrhr<\/jats:italic> was consistently expressed after birth in the rat but not the mouse hippocampus. Similar discrepancies were observed in foetal and adult testes. The ability of the rat promoter to drive reporter gene expression in the hippocampus and testis of transgenic mice just as it naturally directs the expression of the endogenous <jats:italic>Gnrhr<\/jats:italic> in rats strongly suggests that regulatory <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> sequences contained species\u2010specific instructions prevailing over other controls. The major conclusion emerging from these studies is that <jats:italic>Gnrhr<\/jats:italic> promoter sequences are mainly responsible for directing transcriptional programmes and play a predominant role over the species\u2010specific cell environment.<\/jats:p>","DOI":"10.1111\/jne.12253","type":"journal-article","created":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T07:49:51Z","timestamp":1420271391000},"page":"177-186","source":"Crossref","is-referenced-by-count":7,"title":["Inside and Outside the Pituitary: Comparative Analysis of <i>Gnrhr<\/i> Expression Provides Insight into the Mechanisms Underlying the Evolution of Gene Expression"],"prefix":"10.1111","volume":"27","author":[{"given":"AL","family":"Schang","sequence":"first","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Biologie Fonctionnelle et Adaptative Universit\u00e9 Paris Diderot, Paris 7 CNRS 8251 Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Epig\u00e9n\u00e9tique et Destin Cellulaire Universite Paris Diderot, 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