{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:53:35Z","timestamp":1787828015357,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Hyperactivity of the hypothalamic\u2010pituitary\u2010adrenal (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>) axis has been reported in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>untington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>). In non\u2010<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> populations, alterations in <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis activity have been associated with depression and suicidality. The present study aims to compare <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis activity between <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mutation carriers and controls, and examine its association with depressive symptoms and suicidality. To this end, salivary cortisol concentrations at seven time points, as well as depressive symptoms and suicidality, were assessed in 49 pre\u2010motor, 102 motor symptomatic mutation carriers and 55 controls, at baseline and follow\u2010up combined. Differences in parameters of <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis activity between these three groups, and their associations with depressive symptoms and suicidality in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mutation carriers, were analysed using multilevel regression analyses. There were no differences in parameters of <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis activity between mutation carriers and controls, whereas pre\u2010motor symptomatic mutation carriers had a significantly higher area under the curve to the increase (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>i<\/jats:sub>) compared to motor symptomatic mutation carriers. In the entire <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> cohort, <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis activity was not associated with depressive symptoms or suicidality. After stratifying mutation carriers into pre\u2010motor, early and advanced disease stages, \u03b2 values differed between these groups. Remarkably, a higher <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>i<\/jats:sub> was significantly associated with depressive symptoms in pre\u2010motor and early disease stage mutation carriers, with a reverse nonsignificant association in advanced disease stage mutation carriers. The lower <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>i<\/jats:sub> in motor symptomatic mutation carriers and the varying associations with depressive symptoms and suicidality in pre\u2010motor, early and advanced disease stages could possibly be explained by exhaustion of the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis after prolonged stress\u2010induced <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis hyperactivity and deserves further longitudinal study.<\/jats:p>","DOI":"10.1111\/jne.12255","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T14:40:05Z","timestamp":1420555205000},"page":"234-244","source":"Crossref","is-referenced-by-count":35,"title":["Hypothalamic\u2010Pituitary\u2010Adrenal Axis Functioning in Huntington's Disease and its Association with Depressive Symptoms and Suicidality"],"prefix":"10.1111","volume":"27","author":[{"given":"A. A. 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