{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:22Z","timestamp":1771632022389,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>In seasonal mammals living in temperate zones, photoperiod regulates prolactin secretion, such that prolactin plasma concentrations peak during the summer months and are lowest during the winter. In sheep, a short\u2010day breeder, circulating prolactin has important modulatory effects on the reproductive system via inhibitory actions on pituitary gonadotrophs and hypothalamic gonadotrophin\u2010releasing hormone release. The exact cellular mechanisms that account for the chronic hypersecretion of prolactin during the summer is not known, although evidence supports an intrapituitary mechanism regulated by melatonin. Folliculo\u2010stellate (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>) cells are non\u2010endocrine cells that play a crucial role in paracrine communication within the pituitary and produce factors controlling prolactin and gonadotrophin release. The present study examined the morphology of the<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>and lactotroph cell populations and their distribution in the sheep pituitary during the annual reproductive cycle. Ovine pituitary glands were collected in the winter (breeding season;<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>) and summer (nonbreeding season;<jats:styled-content style=\"fixed-case\">NBS<\/jats:styled-content>) and were prepared for quantitative electron microscopy to assess the effects of season on<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>and lactotroph cell density, morphology and distribution, as well as on junctional contacts between cells. It was found that lactotrophs in the<jats:styled-content style=\"fixed-case\">NBS<\/jats:styled-content>are larger in size and contain more numerous<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>granules than lactotrophs in the<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>cells were also larger in the<jats:styled-content style=\"fixed-case\">NBS<\/jats:styled-content>compared to<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>and showed altered morphology such that, in the<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>, long cell processes surrounded clusters of adjacent secretory cells. Although no significant change in the number of junctions was observed between lactotrophs and<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>cells, or lactotrophs and gonadotrophs, there was a significant increase in the number of adherens junctions between lactotrophs and between<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>cells. These findings demonstrate seasonal plasticity in the morphology of lactotrophs and<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>cells that reflect changes in<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>secretion.<\/jats:p>","DOI":"10.1111\/jne.12261","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T11:40:57Z","timestamp":1423050057000},"page":"277-284","source":"Crossref","is-referenced-by-count":16,"title":["Ultrastructural Changes in Lactotrophs and Folliculo\u2010Stellate Cells in the Ovine Pituitary during the Annual Reproductive Cycle"],"prefix":"10.1111","volume":"27","author":[{"given":"H. 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