{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:14:49Z","timestamp":1788948889406,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R21 MH087806"],"award-info":[{"award-number":["R21 MH087806"]}]},{"name":"NIH","award":["R01 MH085069"],"award-info":[{"award-number":["R01 MH085069"]}]},{"DOI":"10.13039\/100007602","name":"University of California, Riverside","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007602","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Fatherhood in biparental mammals is accompanied by distinct neuroendocrine changes in males, involving some of the same hormones involved in maternal care. In the monogamous, biparental California mouse (<jats:italic>Peromyscus californicus<\/jats:italic>), paternal care has been linked to changes in the central and\/or peripheral availability of oestrogen, progesterone, vasopressin and oxytocin, although it is not known whether these endocrine fluctuations are associated with changes in receptor availability in the brain. Thus, we compared <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of oestrogen receptor (<jats:styled-content style=\"fixed-case\">ER)<\/jats:styled-content>\u03b1, progesterone receptor (PR), vasopressin receptor (V1a) and oxytocin receptor (OTR) in brain regions implicated in paternal care [i.e. medial preoptic area (<jats:styled-content style=\"fixed-case\">MPOA<\/jats:styled-content>)], fear [i.e. medial amygdala (MeA)] and anxiety [i.e. bed nucleus of the stria terminalis (<jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content>)] between first\u2010time fathers (n<jats:bold>\u00a0<\/jats:bold>=<jats:bold>\u00a0<\/jats:bold>8) and age\u2010matched virgin males (n\u00a0=\u00a07). Males from both reproductive conditions behaved paternally towards unrelated pups, whereas fathers showed significantly shorter latencies to behave paternally and less time investigating pups. Furthermore, fathers showed significantly lower PR, OTR and V1a receptor <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in the <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> compared to virgins. Fathers also showed a marginally significant (P\u00a0=\u00a00.07) reduction in progesterone receptor <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in the <jats:styled-content style=\"fixed-case\">MPOA<\/jats:styled-content>, although fatherhood was not associated with any other changes in receptor <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">MPOA<\/jats:styled-content> or MeA. The results of the present study indicate that behavioural and endocrine changes associated with the onset of fatherhood, and\/or with cohabitation with a (breeding) female, are accompanied by changes in <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of hormone and neuropeptide receptors in the brain.<\/jats:p>","DOI":"10.1111\/jne.12264","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T15:18:50Z","timestamp":1423322330000},"page":"245-252","source":"Crossref","is-referenced-by-count":51,"title":["Effects of Reproductive Experience on Central Expression of Progesterone, Oestrogen \u03b1, Oxytocin and Vasopressin Receptor <scp>mRNA<\/scp> in Male California Mice (<i>Peromyscus californicus<\/i>)"],"prefix":"10.1111","volume":"27","author":[{"given":"J. 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