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In the first experiment, application of antibody against tyrosine hydroxylase (<jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content>; a marker for <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>) in brain sections revealed the presence of intensely stained <jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content> immunoreactive cells in the preoptic area (<jats:styled-content style=\"fixed-case\">POA<\/jats:styled-content>) and nucleus preopticus (<jats:styled-content style=\"fixed-case\">NPO<\/jats:styled-content>) during the previtellogenic phase. These cells showed weak immunoreactivity during the vitellogenic and prespawning phases concomitant with darkly stained luteinising hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) immunoreactive content in the proximal pars distalis (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) of the pituitary gland and fully ripened follicles (stage V) in the ovary of control fish. However, in fish exposed to aquacultural stressors, <jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content> secreting cells remained intensely stained in <jats:styled-content style=\"fixed-case\">POA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NPO<\/jats:styled-content> regions during the prespawning phase, indicating increased synthetic and secretory activity, which was reflected by a significantly higher <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> content compared to controls. Increased <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> activity as a result of stress was associated with a decrease in the <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> immunoreactive content in the <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> and an absence of stage V follicles in the ovary. In the second experiment, administration of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> caused effects similar to those in stressed fish, whereas <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> receptor antagonist domperidone (<jats:styled-content style=\"fixed-case\">DOM<\/jats:styled-content>) treatment significantly increased the <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> content in the <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> and the number of stage V follicles in unstressed fish. On the other hand, treatment of stressed fish with <jats:styled-content style=\"fixed-case\">DOM<\/jats:styled-content> resulted in dark accumulations of <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> immunoreactive content in the <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> accompanied by the presence of stage V follicles in the ovary. Taken together, these results suggest an additional pathway for the inhibitory effects of stress through dopaminergic neurones along the reproductive axis.<\/jats:p>","DOI":"10.1111\/jne.12269","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T17:01:31Z","timestamp":1424797291000},"page":"343-356","source":"Crossref","is-referenced-by-count":26,"title":["Evidence for the Involvement of Dopamine in Stress\u2010Induced Suppression of Reproduction in the Cichlid Fish <i>Oreochromis mossambicus<\/i>"],"prefix":"10.1111","volume":"27","author":[{"given":"A.","family":"Chabbi","sequence":"first","affiliation":[{"name":"Neuroendocrinology Research Lab Department of Studies in Zoology Karnatak University Dharwad Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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