{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:57Z","timestamp":1788870117634,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Program on Key Basic Research Project of China","award":["2012CB517505"],"award-info":[{"award-number":["2012CB517505"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270947"],"award-info":[{"award-number":["81270947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Doctoral Fund of Ministry of Education of China","award":["20115503110008"],"award-info":[{"award-number":["20115503110008"]}]},{"name":"Natural Science Foundation Project of Chongqing","award":["2010BB5370"],"award-info":[{"award-number":["2010BB5370"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>\n                    The prevalence of obesity among child\u2010bearing women has increased significantly. The adverse consequences of maternal obesity on the descendants have been well accepted, although few studies have examined the underlying mechanisms. We investigated whether neonatal overfeeding in female mice alters metabolic phenotypes in the offspring and whether hypothalamic leptin signalling is involved. Neonatal overfeeding was induced by reducing the litter size to three pups per litter, in contrast to normal litter size of 10\u00a0pups per litter. Normal and neonatally overfed female mice were bred with normal male mice, and offspring of overfeeding mothers (\n                    <jats:styled-content style=\"fixed-case\">OOM<\/jats:styled-content>\n                    ) and control mothers (\n                    <jats:styled-content style=\"fixed-case\">OCM<\/jats:styled-content>\n                    ) were generated. We examined body weight, daily food intake, leptin responsiveness and the number of positive neurones for phosphorylated\u2010signal transducer and activator of transcription 3 (\n                    <jats:styled-content style=\"fixed-case\">pSTAT<\/jats:styled-content>\n                    3) along with neuropeptide Y (\n                    <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\n                    ) in the arcuate nucleus of the hypothalamus (\n                    <jats:styled-content style=\"fixed-case\">ARH<\/jats:styled-content>\n                    ) and\n                    <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\n                    in the nucleus tractus solitarius (\n                    <jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>\n                    ) of the brain stem. The body weight and daily food intake of\n                    <jats:styled-content style=\"fixed-case\">OOM<\/jats:styled-content>\n                    were significantly higher than those of\n                    <jats:styled-content style=\"fixed-case\">OCM<\/jats:styled-content>\n                    . Leptin significantly reduced food intake and increased the number of\n                    <jats:styled-content style=\"fixed-case\">pSTAT<\/jats:styled-content>\n                    3 positive neurones in the\n                    <jats:styled-content style=\"fixed-case\">ARH<\/jats:styled-content>\n                    of\n                    <jats:styled-content style=\"fixed-case\">OCM<\/jats:styled-content>\n                    mice, whereas no significant changes in food intake and\n                    <jats:styled-content style=\"fixed-case\">pSTAT<\/jats:styled-content>\n                    3 neurones were found in leptin\u2010treated\n                    <jats:styled-content style=\"fixed-case\">OOM<\/jats:styled-content>\n                    mice. The number of\n                    <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\n                    neurones in the\n                    <jats:styled-content style=\"fixed-case\">ARH<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>\n                    of the\n                    <jats:styled-content style=\"fixed-case\">OOM<\/jats:styled-content>\n                    mice was significantly higher than that of\n                    <jats:styled-content style=\"fixed-case\">OCM<\/jats:styled-content>\n                    mice. The results of the present study indicate that the obese phenotype from mothers can be passed onto the subsequent generation, which is possibly associated with hypothalamic leptin resistance.\n                  <\/jats:p>","DOI":"10.1111\/jne.12281","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T22:36:26Z","timestamp":1428532586000},"page":"600-608","source":"Crossref","is-referenced-by-count":18,"title":["Neonatal Overfeeding in Female Mice Predisposes the Development of Obesity in their Male Offspring via Altered Central Leptin Signalling"],"prefix":"10.1111","volume":"27","author":[{"given":"H.","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Lipid &amp; Glucose Metabolism The First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital Chongqing Medical University Chongqing 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