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We have previously shown that<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>attenuates cocaine\u2010seeking behaviour, and also that<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>decreases corticosterone (<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>) levels in plasma and the prefrontal cortex. Previous studies have found that rats demonstrate cocaine\u2010seeking behaviour only when the level of<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>reaches a minimum threshold. In the present study, we investigated whether the attenuating effect of<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>on cocaine seeking is a result of it reducing<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>levels rather than a result of any unique neurosteroid properties. Rats received either daily<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>injections (2\u00a0mg\/kg, i.p.) alone, daily<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>(2\u00a0mg\/kg, i.p.) with<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>infusion (to maintain stable basal levels of<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>; 15\u00a0mg\/kg, s.c.) or vehicle (i.p.) as control, throughout self\u2010administration training and extinction sessions. We found that both<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\u2010treated and<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>\u2010treated groups showed a significantly lower number of active lever presses compared to controls throughout training and extinction sessions, as well as at cocaine\u2010primed reinstatement.<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\u2010treated rats showed lower<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>levels throughout the experimental phases compared to<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>\u2010treated and control rats. Additionally, we show that<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>administered to cocaine\u2010trained rats throughout extinction sessions, or immediately before reinstatement, attenuated cocaine seeking. These findings indicate that<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>attenuates cocaine\u2010seeking behaviour independently of fluctuations in<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>levels.<\/jats:p>","DOI":"10.1111\/jne.12322","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T15:08:52Z","timestamp":1440601732000},"page":"819-826","source":"Crossref","is-referenced-by-count":3,"title":["Dehydroepiandrosterone Attenuates Cocaine\u2010Seeking Behaviour Independently of Corticosterone Fluctuations"],"prefix":"10.1111","volume":"27","author":[{"given":"R.","family":"Maayan","sequence":"first","affiliation":[{"name":"The Laboratory of Biological Psychiatry Felsenstein Medical Research Center and Sackler Faculty of Medicine Tel Aviv University Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hirsh","sequence":"additional","affiliation":[{"name":"Leslie and Gonda (Goldschmied) Multidisciplinary Brain Research Center Faculty of Life Sciences Bar\u2010Ilan University Ramat\u2010Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Yadid","sequence":"additional","affiliation":[{"name":"Leslie and Gonda (Goldschmied) Multidisciplinary Brain Research Center Faculty of Life Sciences Bar\u2010Ilan University Ramat\u2010Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Weizman","sequence":"additional","affiliation":[{"name":"The Laboratory of Biological Psychiatry Felsenstein Medical Research Center and Sackler Faculty of Medicine Tel Aviv University Petah Tikva Israel"},{"name":"Geha Mental Health Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00036-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(00)00098-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00027-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.785"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2009.10.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00206-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.05.039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000127137"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00034-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09011.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0022-3565(24)36712-6","article-title":"Glucocorticoids and behavioral effects of psychostimulants. 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