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Although the specific mechanisms linking stress exposure and AD vulnerability have yet to be fully determined, our laboratory and others have shown that acute and repeated restraint stress in rodents leads to an increase in hippocampal tau phosphorylation (tau\u2010P) and tau insolubility, a critical component of tau pathology in AD. Although tau phosphorylation induced by acute psychological stress is dependent on intact signaling through the type 1 corticotropin\u2010releasing factor receptor, how sex steroids or other modulators contribute to this effect is unknown. A naturally occurring attenuation of the stress response is observed in female rats at the end of pregnancy and throughout lactation. To test the hypothesis that decreased sensitivity to stress during lactation modulates stress\u2010induced tau\u2010P, cohorts of virgin, lactating and weaned female rats were subjected to 30 min of restraint stress or no stress (control) and were killed 20 min or 24 h after the episode. Exposure to restraint stress induced a significant decrease in tau\u2010P in the hippocampus of lactating rats killed 20 min after stress compared to lactating controls and virgins subjected to stress treatment. Lactating rats killed 24hr after restraint stress exposure showed significant elevation in tau\u2010P compared to lactating cohorts killed 20 min after stress. Levels of tau\u2010P in these latter cohorts did not differ signficantly from control animals. Furthermore, glycogen synthase kinase (GSK)3\u2010\u03b1 levels were significantly decreased in stressed lactating animals at both timepoints. This suggests a steep, yet transient stress\u2010induced dephosphorylation of tau, influenced by GSK3, in the hippocampus of lactating rats.<\/jats:p>","DOI":"10.1111\/jne.12323","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T08:16:42Z","timestamp":1441613802000},"page":"827-834","source":"Crossref","is-referenced-by-count":14,"title":["Reproductive Stage and Modulation of Stress\u2010Induced Tau Phosphorylation in Female Rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Danielle","family":"Steinmetz","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego, La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Ramos","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiologia Universidad Nacional Autonoma de Mexico Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon 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