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Several previous studies on lactating sheep and rats have reported that salsolinol plays a crucial role in the regulation of prolactin secretion. The present study investigated the effects of salsolinol, which was infused into the third ventricle of the brain, on oxytocin expression and release in lactating sheep, 48\u00a0h after weaning of 8\u2010week\u2010old lambs. Serial 30\u2010min infusions of salsolinol and vehicle were performed at 30\u2010min intervals from 10.00 to 15.00\u00a0h. Blood samples were collected every 10\u00a0min. The supraoptic nucleus (<jats:styled-content style=\"fixed-case\">SON<\/jats:styled-content>), paraventricular nucleus (<jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>) and posterior pituitary were collected immediately after the experiment. Expression levels of<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s for oxytocin and peptidylglycine \u03b1\u2010amidating monooxygenase (<jats:styled-content style=\"fixed-case\">PAM<\/jats:styled-content>), the terminal enzyme in the oxytocin synthesis pathway, were measured using a real\u2010time polymerase chain reaction. Oxytocin peptide content in the posterior pituitary was measured by an enzyme\u2010linked immunosorbent assay, and plasma oxytocin concentration was measured by radioimmunoassay. Salsolinol treatment significantly up\u2010regulated oxytocin and<jats:styled-content style=\"fixed-case\">PAM<\/jats:styled-content>gene expression in the<jats:styled-content style=\"fixed-case\">SON<\/jats:styled-content>(P\u00a0&lt;\u00a00.01 and P\u00a0&lt;\u00a00.05, respectively),<jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>(P\u00a0&lt;\u00a00.01 and P\u00a0&lt;\u00a00.05, respectively) and posterior pituitary (P\u00a0&lt;\u00a00.05 and P\u00a0&lt;\u00a00.05, respectively). Oxytocin peptide content in the posterior pituitary and the area under the response curve of plasma oxytocin were significantly (P\u00a0&lt;\u00a00.05 and P\u00a0&lt;\u00a00.01, respectively) higher in salsolinol\u2010treated sheep than in control animals. The present study shows for the first time that salsolinol stimulates oxytocin secretion during lactation in sheep.<\/jats:p>","DOI":"10.1111\/jne.12362","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T11:53:51Z","timestamp":1452426831000},"source":"Crossref","is-referenced-by-count":12,"title":["Salsolinol Up\u2010Regulates Oxytocin Expression and Release During Lactation in Sheep"],"prefix":"10.1111","volume":"28","author":[{"given":"K.","family":"G\u00f3rski","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Sciences Jab\u0142onna Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Sciences Jab\u0142onna 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