{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:40:35Z","timestamp":1787312435099,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_1449493"],"award-info":[{"award-number":["320030_1449493"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>\n                    Lysergic acid diethylamide (LSD) is a serotonin 5\u2010hydroxytryptamine\u20102A (5\u2010HT\n                    <jats:sub>2A<\/jats:sub>\n                    ) receptor agonist that is used recreationally worldwide. Interest in LSD research in humans waned after the 1970s, although the use of LSD in psychiatric research and practice has recently gained increasing attention. LSD produces pronounced acute psychedelic effects, although its influence on plasma steroid levels over time has not yet been characterised in humans. The effects of LSD (200\u00a0\u03bcg) or placebo on plasma steroid levels were investigated in 16 healthy subjects using a randomised, double\u2010blind, placebo\u2010controlled, cross\u2010over study design. Plasma concentration\u2013time profiles were determined for 15 steroids using liquid\u2010chromatography tandem mass\u2010spectrometry. LSD increased plasma concentrations of the glucocorticoids cortisol, cortisone, corticosterone and 11\u2010dehydrocorticosterone compared to placebo. The mean maximum concentration of LSD was reached at 1.7\u00a0h. Mean peak psychedelic effects were reached at 2.4\u00a0h, with significant alterations in mental state from 0.5\u00a0h to &gt;\u00a010\u00a0h. Mean maximal concentrations of cortisol and corticosterone were reached at 2.5\u00a0h and 1.9\u00a0h, and significant elevations were observed 1.5\u20136\u00a0h and 1\u20133\u00a0h after drug administration, respectively. LSD also significantly increased plasma concentrations of the androgen dehydroepiandrosterone but not other androgens, progestogens or mineralocorticoids compared to placebo. A close relationship was found between plasma LSD concentrations and changes in plasma cortisol and corticosterone and the psychotropic response to LSD, and no clockwise hysteresis was observed. In conclusion, LSD produces significant acute effects on circulating steroids, especially glucocorticoids. LSD\u2010induced changes in circulating glucocorticoids were associated with plasma LSD concentrations over time and showed no acute pharmacological tolerance.\n                  <\/jats:p>","DOI":"10.1111\/jne.12374","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T06:13:13Z","timestamp":1454739193000},"source":"Crossref","is-referenced-by-count":66,"title":["Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects"],"prefix":"10.1111","volume":"28","author":[{"given":"P.","family":"Strajhar","sequence":"first","affiliation":[{"name":"Division of Molecular and Systems Toxicology Department of Pharmaceutical Sciences University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology Department of Biomedicine and Department of Clinical Research University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Liakoni","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology Department of Biomedicine and Department of Clinical Research University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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