{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:51:37Z","timestamp":1760187097415,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00e3o Paulo State Research Foundation - FAPESP","award":["N 2005\/5125-3"],"award-info":[{"award-number":["N 2005\/5125-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Besides their well\u2010established endocrine roles, vasopressin and oxytocin are also important regulators of immune function, participating in a complex neuroendocrine\u2013immune network. In the present study, we investigated whether and how vasopressin and oxytocin could modulate lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>)\u2010induced nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) production in a well\u2010established model of experimental endotoxaemia. Male Wistar rats were previously treated i.v. with vasopressin V<jats:sub>1<\/jats:sub> or oxytocin receptor antagonists and then received either an i.v. <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> injection to induce endotoxaemia or a saline imjection as a control. The animals were divided into two groups: in the first group, blood was collected at 2, 4 and 6\u00a0h after <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> injection; in the second group, mean arterial blood pressure (<jats:styled-content style=\"fixed-case\">MABP<\/jats:styled-content>) and heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) were recorded over 6\u00a0h. Plasma vasopressin and oxytocin values were higher in <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010 compared to saline\u2010injected animals at 2 and 4\u00a0h but returned to basal levels at 6\u00a0h. <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> levels exhibited an opposite pattern, showing a progressive increase over the entire period. The previous administration of a vasopressin V<jats:sub>1<\/jats:sub> receptor antagonist significantly reduced <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> plasma concentrations at 2 and 4\u00a0h but not at 6\u00a0h. By contrast, oxytocin receptor agonist pre\u2010treatment had no effect on the <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> plasma concentration. In relation to <jats:styled-content style=\"fixed-case\">MABP<\/jats:styled-content>, previous treatment with vasopressin V<jats:sub>1<\/jats:sub> receptor antagonist reversed the <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced hypotension at 4\u00a0h, although this was not the case for oxytocin antagonist\u2010treated animals. None of the antagonists affected <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>. Our findings indicate that vasopressin (but not oxytocin) has effects on <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> production during endotoxaemia in rats, although they do not lend support to the proposed anti\u2010inflammatory actions of vasopressin during endotoxaemia.<\/jats:p>","DOI":"10.1111\/jne.12391","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T20:27:13Z","timestamp":1459628833000},"source":"Crossref","is-referenced-by-count":3,"title":["Differential Role of Neurohypophysial Hormones in Hypotension and Nitric Oxide Production During Endotoxaemia"],"prefix":"10.1111","volume":"28","author":[{"given":"A. M.","family":"Stabile","sequence":"first","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Moreto","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Batalh\u00e3o","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Rocha","sequence":"additional","affiliation":[{"name":"School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Antunes\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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