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In the present study, we examined <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content> expression in the hypothalamo\u2010spinal pathway, as well as the hypothalamo\u2010neurohypophysial system, which includes the magnocellular neurosecretory cells in the <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content> and the supraoptic nucleus (<jats:styled-content style=\"fixed-case\">SON<\/jats:styled-content>), after s.c. injection of saline or formalin into the hindpaws of transgenic rats that express the <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content> and monomeric red fluorescent protein 1 (<jats:styled-content style=\"fixed-case\">mRFP<\/jats:styled-content>1) fusion gene. (i) The numbers of <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRFP<\/jats:styled-content>1 neurones that expressed Fos\u2010like immunoreactivity (\u2010IR) and <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRFP<\/jats:styled-content>1 intensity were increased significantly in the magnocellular\/parvocellular <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SON<\/jats:styled-content> after s.c. injection of formalin. (ii) <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRFP<\/jats:styled-content>1 neurones in the anterior parvocellular <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>, which may project to the dorsal horn of the spinal cord, were activated by s.c. injection of formalin, as indicated by a significant increases of Fos\u2010IR and <jats:styled-content style=\"fixed-case\">mRFP<\/jats:styled-content>1 intensity intensity. (iii) Formalin injection caused a significant transient increase in plasma <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>. (iv) <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> mRFP<\/jats:styled-content>1 and corticotrophin\u2010releasing hormone <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content> were significantly increased after s.c. injection of formalin. (v) An intrathecal injection of <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>\u2010saporin induced hypersensitivity in conscious rats. Taken together, these results suggest that the hypothalamo\u2010neurohypophysial\/\u2010spinal <jats:styled-content style=\"fixed-case\">OXT<\/jats:styled-content>ergic pathways may be involved in acute nociceptive responses in rats.<\/jats:p>","DOI":"10.1111\/jne.12396","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T19:34:48Z","timestamp":1462390488000},"source":"Crossref","is-referenced-by-count":32,"title":["Possible Involvement of the Rat Hypothalamo\u2010Neurohypophysial\/\u2010Spinal Oxytocinergic Pathways in Acute Nociceptive Responses"],"prefix":"10.1111","volume":"28","author":[{"given":"T.","family":"Matsuura","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine University of Occupational and Environmental Health Kitakyushu Japan"},{"name":"Department of Orthopaedics School of Medicine University of Occupational and Environmental Health Kitakyushu 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