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It is a relevant source of many polypeptides secreted to the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> with neuroprotective functions and also participates in the elimination and detoxification of brain metabolites, such as \u03b2\u2010amyloid (A\u03b2) removal from the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> through transporter\u2010mediated influx. The <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> is also a target tissue for sex hormones (<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>s) that have recognised neuroprotective effects against a variety of insults, including A\u03b2 toxicity and oxidative stress in the central nervous system. The present study aimed to understand how <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>s modulate A\u03b2\u2010induced oxidative stress in a <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> cell line (Z310 cell line) by analysing the effects of A\u03b2<jats:sub>1\u201342<\/jats:sub> on oxidative stress, mitochondrial function and apoptosis, as well as by assessing how 17\u03b2\u2010oestradiol (E<jats:sub>2<\/jats:sub>) and 5\u03b1\u2010dihydrotestosterone (<jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content>) modulated these effects and the cellular uptake of A\u03b2<jats:sub>1\u201342<\/jats:sub> by <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> cells. Our findings show that E<jats:sub>2<\/jats:sub> and <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> treatment reduce A\u03b2<jats:sub>1\u201342<\/jats:sub>\u2010induced oxidative stress and the internalisation of A\u03b2<jats:sub>1\u201342<\/jats:sub> by <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> epithelial cells, highlighting the importance of considering the background of <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>s and therefore sex\u2010related differences in A\u03b2 metabolism and clearance by <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> cells.<\/jats:p>","DOI":"10.1111\/jne.12404","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T22:06:30Z","timestamp":1466633190000},"source":"Crossref","is-referenced-by-count":11,"title":["Sex Hormones Protect Against Amyloid\u2010\u03b2 Induced Oxidative Stress in the Choroid Plexus Cell Line Z310"],"prefix":"10.1111","volume":"28","author":[{"given":"A. 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